Source:http://linkedlifedata.com/resource/pubmed/id/12402208
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2002-10-28
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| pubmed:abstractText |
Antibody persistence and immunological priming for 2 formulations of a meningococcal group C (menC) conjugate (MCC) vaccine (containing 2 or 10 microg of menC polysaccharide) administered at 2, 3, and 4 months of age was investigated by boosting vaccine recipients at age 13-16 months or 4 years with 10 microg of unconjugated menC polysaccharide. At age 4 years, geometric mean titers (GMTs) and concentrations of menC-specific immunoglobulin G and serum bactericidal antibody (SBA) had decreased to prevaccination levels. Geometric mean avidity indices increased after the primary vaccination until age 13-16 months and then remained constant until age 4 years. One month after boosting at age 4 years, menC immunoglobulin G and SBA levels increased significantly. The postbooster SBA GMT for the 2-microg vaccination (2181.2; 95% confidence interval [CI], 975.9-4875.1) was 2-fold higher than that for the 10-microg vaccination (931.6; 95% CI, 338.0-2568.1). This is the first demonstration of immunological memory at 4 years of age in children receiving MCC vaccine on the United Kingdom's 2/3/4-month immunization schedule.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0022-1899
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
1
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| pubmed:volume |
186
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1353-7
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12402208-Antibodies, Bacterial,
pubmed-meshheading:12402208-Antibody Formation,
pubmed-meshheading:12402208-Antibody Specificity,
pubmed-meshheading:12402208-Child,
pubmed-meshheading:12402208-Child, Preschool,
pubmed-meshheading:12402208-Follow-Up Studies,
pubmed-meshheading:12402208-Great Britain,
pubmed-meshheading:12402208-Humans,
pubmed-meshheading:12402208-Immunoglobulin G,
pubmed-meshheading:12402208-Immunologic Memory,
pubmed-meshheading:12402208-Meningococcal Infections,
pubmed-meshheading:12402208-Neisseria meningitidis,
pubmed-meshheading:12402208-Time Factors,
pubmed-meshheading:12402208-Vaccines, Conjugate
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Antibody persistence and immunological memory at age 4 years after meningococcal group C conjugate vaccination in children in the United kingdom.
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| pubmed:affiliation |
Public Health Laboratory Service Meningococcal Reference Unit, Withington Hospital, Manchester, United Kingdom. rborrow@nw.phls.org.uk
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| pubmed:publicationType |
Journal Article
|