12400959

Source:http://linkedlifedata.com/resource/pubmed/id/12400959

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0178602, umls-concept:C0439849, umls-concept:C0439857, umls-concept:C0449468, umls-concept:C0596263, umls-concept:C1428114, umls-concept:C1517600, umls-concept:C1522449
pubmed:issue	3A
pubmed:dateCreated	2002-10-28
pubmed:abstractText	The present study was initiated to identify radiotherapy-related parameters influencing the development of second malignancies. Between 1969 and 1989, about 31000 patients were treated with radiotherapy in Dresden. Of these, 203 were re-admitted for radiotherapy of a newly developed malignancy. Based on completeness of documentation, definition of site of origin and exclusion of recurrent or metastatic tumours, 85 patients were selected for analysis of spatial relation between new tumour and primary treatment fields, and of dose at the site of origin. The majority of second tumours were seen within the margin region of the treatment volume, defined as the volume from 2.5 cm inside to 5 cm outside the margin of the planning target volume (PTV). Fewer than 10% of the second tumours occurred inside the PTV and 11% developed outside the margin region. The majority of second tumours were observed in the volume receiving <6 Gy. Similar results were obtained in a group of 31 patients initially irradiated for benign diseases. This should be considered in radiotherapy, particularly with multiple-field techniques or intensity-modulated radiotherapy, where the volume receiving <6 Gy is substantially increased.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8809257
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0952-4746
pubmed:author	pubmed-author:DörrWolfgangW, pubmed-author:HerrmannThomasT
pubmed:issnType	Print
pubmed:volume	22
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	A117-21
pubmed:dateRevised	2004-11-17
pubmed:meshHeading	pubmed-meshheading:12400959-Humans, pubmed-meshheading:12400959-Neoplasms, Radiation-Induced, pubmed-meshheading:12400959-Neoplasms, Second Primary, pubmed-meshheading:12400959-Radiotherapy, pubmed-meshheading:12400959-Radiotherapy Dosage
pubmed:year	2002
pubmed:articleTitle	Cancer induction by radiotherapy: dose dependence and spatial relationship to irradiated volume.
pubmed:affiliation	Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Medizinische Fakultät Carl Gustav Carus der Technischen Universität, Dresden, Germany.
pubmed:publicationType	Journal Article