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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5594
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pubmed:dateCreated |
2002-10-25
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pubmed:abstractText |
We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:Bar-JosephZivZ,
pubmed-author:FraenkelErnestE,
pubmed-author:GerberGeorg KGK,
pubmed-author:GiffordDavid KDK,
pubmed-author:GordonD BenjaminDB,
pubmed-author:HannettNancy MNM,
pubmed-author:HarbisonChristopher TCT,
pubmed-author:JenningsEzra GEG,
pubmed-author:LeeTong IhnTI,
pubmed-author:MurrayHeather LHL,
pubmed-author:OdomDuncan TDT,
pubmed-author:RenBingB,
pubmed-author:RinaldiNicola JNJ,
pubmed-author:RobertFrançoisF,
pubmed-author:SimonItamarI,
pubmed-author:TagneJean-BoscoJB,
pubmed-author:ThompsonCraig MCM,
pubmed-author:VolkertThomas LTL,
pubmed-author:WyrickJohn JJJ,
pubmed-author:YoungRichard ARA,
pubmed-author:ZeitlingerJuliaJ
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
298
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
799-804
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12399584-Algorithms,
pubmed-meshheading:12399584-Cell Cycle,
pubmed-meshheading:12399584-Computational Biology,
pubmed-meshheading:12399584-DNA, Fungal,
pubmed-meshheading:12399584-Feedback, Physiological,
pubmed-meshheading:12399584-Gene Expression Profiling,
pubmed-meshheading:12399584-Gene Expression Regulation, Fungal,
pubmed-meshheading:12399584-Genes, Fungal,
pubmed-meshheading:12399584-Genome, Fungal,
pubmed-meshheading:12399584-Models, Genetic,
pubmed-meshheading:12399584-Promoter Regions, Genetic,
pubmed-meshheading:12399584-Protein Binding,
pubmed-meshheading:12399584-Saccharomyces cerevisiae,
pubmed-meshheading:12399584-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:12399584-Transcription, Genetic,
pubmed-meshheading:12399584-Transcription Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Transcriptional regulatory networks in Saccharomyces cerevisiae.
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pubmed:affiliation |
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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