rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-10-25
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pubmed:abstractText |
The aim of this study was to analyze the expression of SNAP-25 and syntaxin-1 in the adenohypophyses of hypothyroid rats. Rats were divided into: 1) controls; 2) thyroidectomized 40 days; and 3) thyroidectomized 40 days with replacement of T4 20 days after surgery. Adenohypophyses were studied by immunohistochemistry and immunoblot analysis using antibodies against SNAP-25, syntaxin-1 and TSH. By immunostaining, SNAP-25 and syntaxin-1 were conspicuous and were localized around cytoplasmic vacuoles of thyroidectomy cells. Immunoblot analysis shows that thyroidectomy increases adenohypophysial SNAP-25 expression and decreases syntaxin-1 levels. T4 administration for 20 days produces a recovery similar to control values. In conclusion, thyroidectomy produces changes in both expression and immunoreactivity of SNAP-25 and syntaxin-1 in adenohypophyses of rats and these effects can be reversed by T4 administration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Snap25 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Stx1a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Synaptosomal-Associated Protein 25,
http://linkedlifedata.com/resource/pubmed/chemical/Syntaxin 1,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroxine
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0391-4097
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
754-8
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:12398231-Animals,
pubmed-meshheading:12398231-Antigens, Surface,
pubmed-meshheading:12398231-Female,
pubmed-meshheading:12398231-Hypothyroidism,
pubmed-meshheading:12398231-Immunoblotting,
pubmed-meshheading:12398231-Immunohistochemistry,
pubmed-meshheading:12398231-Membrane Proteins,
pubmed-meshheading:12398231-Nerve Tissue Proteins,
pubmed-meshheading:12398231-Organ Size,
pubmed-meshheading:12398231-Pituitary Gland, Anterior,
pubmed-meshheading:12398231-Rats,
pubmed-meshheading:12398231-Rats, Wistar,
pubmed-meshheading:12398231-Synaptosomal-Associated Protein 25,
pubmed-meshheading:12398231-Syntaxin 1,
pubmed-meshheading:12398231-Thyroidectomy,
pubmed-meshheading:12398231-Thyrotropin,
pubmed-meshheading:12398231-Thyroxine
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pubmed:year |
2002
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pubmed:articleTitle |
Effect of hypothyroidism on synaptosomal-associated protein of 25 kDa and syntaxin-1 expression in adenohypophyses of rat.
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pubmed:affiliation |
Department of Physiology and Pharmacology, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, México. jlquinta@correo.uaa.mx
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pubmed:publicationType |
Journal Article
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