Source:http://linkedlifedata.com/resource/pubmed/id/12397104
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
21
|
| pubmed:dateCreated |
2002-10-24
|
| pubmed:abstractText |
The neural crest is a uniquely vertebrate cell type present in the most basal vertebrates, but not in cephalochordates. We have studied differences in regulation of the neural crest marker AP-2 across two evolutionary transitions: invertebrate to vertebrate, and agnathan to gnathostome. Isolation and comparison of amphioxus, lamprey and axolotl AP-2 reveals its extensive expansion in the vertebrate dorsal neural tube and pharyngeal arches, implying co-option of AP-2 genes by neural crest cells early in vertebrate evolution. Expression in non-neural ectoderm is a conserved feature in amphioxus and vertebrates, suggesting an ancient role for AP-2 genes in this tissue. There is also common expression in subsets of ventrolateral neurons in the anterior neural tube, consistent with a primitive role in brain development. Comparison of AP-2 expression in axolotl and lamprey suggests an elaboration of cranial neural crest patterning in gnathostomes. However, migration of AP-2-expressing neural crest cells medial to the pharyngeal arch mesoderm appears to be a primitive feature retained in all vertebrates. Because AP-2 has essential roles in cranial neural crest differentiation and proliferation, the co-option of AP-2 by neural crest cells in the vertebrate lineage was a potentially crucial event in vertebrate evolution.
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| pubmed:keyword | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0950-1991
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
129
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4953-62
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| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:12397104-Ambystoma,
pubmed-meshheading:12397104-Amino Acid Sequence,
pubmed-meshheading:12397104-Animals,
pubmed-meshheading:12397104-Base Sequence,
pubmed-meshheading:12397104-Body Patterning,
pubmed-meshheading:12397104-Cell Movement,
pubmed-meshheading:12397104-Chordata, Nonvertebrate,
pubmed-meshheading:12397104-DNA, Complementary,
pubmed-meshheading:12397104-DNA-Binding Proteins,
pubmed-meshheading:12397104-Evolution, Molecular,
pubmed-meshheading:12397104-Gene Expression Regulation, Developmental,
pubmed-meshheading:12397104-Lampreys,
pubmed-meshheading:12397104-Molecular Sequence Data,
pubmed-meshheading:12397104-Neural Crest,
pubmed-meshheading:12397104-Phylogeny,
pubmed-meshheading:12397104-Sequence Homology, Amino Acid,
pubmed-meshheading:12397104-Species Specificity,
pubmed-meshheading:12397104-Transcription Factor AP-2,
pubmed-meshheading:12397104-Transcription Factors
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Amphioxus and lamprey AP-2 genes: implications for neural crest evolution and migration patterns.
|
| pubmed:affiliation |
Division of Biology, 139-74, California Institute of Technology, Pasadena 91125, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|