| pubmed-article:12395147 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12395147 | lifeskim:mentions | umls-concept:C0031842 | lld:lifeskim |
| pubmed-article:12395147 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12395147 | lifeskim:mentions | umls-concept:C0389995 | lld:lifeskim |
| pubmed-article:12395147 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:12395147 | lifeskim:mentions | umls-concept:C1412517 | lld:lifeskim |
| pubmed-article:12395147 | lifeskim:mentions | umls-concept:C1423613 | lld:lifeskim |
| pubmed-article:12395147 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12395147 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:12395147 | lifeskim:mentions | umls-concept:C1720675 | lld:lifeskim |
| pubmed-article:12395147 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12395147 | pubmed:dateCreated | 2002-10-23 | lld:pubmed |
| pubmed-article:12395147 | pubmed:abstractText | The small GTPase Rho is implicated in many cellular functions such as cell adhesion, cell motility and migration, growth control, cell contraction, and cytokinesis. One of its main effectors, Rho-kinase, appears to play a key role in the regulation of force and velocity of actomyosin crossbridging in smooth muscle and nonmuscle cells by inhibiting myosin phosphatase-mediated dephosphorylation of the regulatory chain of myosin II. Abnormal activation of the Rho/Rho-kinase pathway has been shown to play a role in diseases such as hypertension and bronchial asthma. This review summarizes the current knowledge on the physiological and pathophysiological function of the Rho/Rho-kinase mediated pathway in various tissues with a focus on its possible role as a target for therapeutic interventions. | lld:pubmed |
| pubmed-article:12395147 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12395147 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12395147 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12395147 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12395147 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12395147 | pubmed:issn | 0946-2716 | lld:pubmed |
| pubmed-article:12395147 | pubmed:author | pubmed-author:OffermannsSte... | lld:pubmed |
| pubmed-article:12395147 | pubmed:author | pubmed-author:WettschureckN... | lld:pubmed |
| pubmed-article:12395147 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12395147 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:12395147 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12395147 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12395147 | pubmed:pagination | 629-38 | lld:pubmed |
| pubmed-article:12395147 | pubmed:dateRevised | 2011-7-8 | lld:pubmed |
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| pubmed-article:12395147 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12395147 | pubmed:articleTitle | Rho/Rho-kinase mediated signaling in physiology and pathophysiology. | lld:pubmed |
| pubmed-article:12395147 | pubmed:affiliation | Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany. | lld:pubmed |
| pubmed-article:12395147 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12395147 | pubmed:publicationType | Review | lld:pubmed |
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