Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2002-10-23
pubmed:abstractText
The small GTPase Rho is implicated in many cellular functions such as cell adhesion, cell motility and migration, growth control, cell contraction, and cytokinesis. One of its main effectors, Rho-kinase, appears to play a key role in the regulation of force and velocity of actomyosin crossbridging in smooth muscle and nonmuscle cells by inhibiting myosin phosphatase-mediated dephosphorylation of the regulatory chain of myosin II. Abnormal activation of the Rho/Rho-kinase pathway has been shown to play a role in diseases such as hypertension and bronchial asthma. This review summarizes the current knowledge on the physiological and pathophysiological function of the Rho/Rho-kinase mediated pathway in various tissues with a focus on its possible role as a target for therapeutic interventions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0946-2716
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
629-38
pubmed:dateRevised
2011-7-8
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Rho/Rho-kinase mediated signaling in physiology and pathophysiology.
pubmed:affiliation
Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
pubmed:publicationType
Journal Article, Review