Linked Life Data

12395091

Source:http://linkedlifedata.com/resource/pubmed/id/12395091

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2002-10-23
pubmed:abstractText
We have examined the levels of constitutively active NF-kappaB subunits p65, p50 and p52 in the hippocampus of aged (24 months) young (3 months) F344 rats. Although we found no significant age-dependent difference in baseline nuclear levels of any subunit, we did note a differential response to treatment with the antioxidant PBN. While PBN significantly reduced nuclear levels of all three subunits in aged rats, only p50 was significantly reduced in the nuclei of young animals. This shows that the impetus for constitutive NF-kappaB activity is different in young and aged animals and may reflect a state of chronic oxidative stress in the latter. In addition this suggests a dysregulation of NF-kappaB and may contribute to the inability of the aged CNS to cope with insults such as trauma and ischemia/reperfusion.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1917-20
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Free radical-dependent changes in constitutive Nuclear factor kappa B in the aged hippocampus.
pubmed:affiliation
Department of Anatomy and Neuroscience, University of Texas Medical Branch at Galveston, TX 77555-1043, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't