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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-10-23
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pubmed:abstractText |
We hypothesized that over expression of c-myc and cyclin D1 genes is transcriptionally activated by beta-catenin mutation independent of gene amplification in bladder cancer. To test this hypothesis we investigated the relationship of beta-catenin mutation to c-myc and cyclin D1 mRNA with special reference to the changes in copy number of the 2 genes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-5347
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2220-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12394763-Carcinoma, Transitional Cell,
pubmed-meshheading:12394763-Cyclin D1,
pubmed-meshheading:12394763-Cytoskeletal Proteins,
pubmed-meshheading:12394763-DNA Mutational Analysis,
pubmed-meshheading:12394763-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12394763-Humans,
pubmed-meshheading:12394763-Mutation, Missense,
pubmed-meshheading:12394763-Neoplasm Staging,
pubmed-meshheading:12394763-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:12394763-RNA, Messenger,
pubmed-meshheading:12394763-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12394763-Trans-Activators,
pubmed-meshheading:12394763-Urinary Bladder,
pubmed-meshheading:12394763-Urinary Bladder Neoplasms,
pubmed-meshheading:12394763-beta Catenin
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pubmed:year |
2002
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pubmed:articleTitle |
Beta-catenin mutations correlate with over expression of C-myc and cyclin D1 Genes in bladder cancer.
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pubmed:affiliation |
Department of Urology, Shimane Medical University, Izumo, Japan.
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pubmed:publicationType |
Journal Article
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