| pubmed-article:12393846 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12393846 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:12393846 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12393846 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:12393846 | lifeskim:mentions | umls-concept:C0015403 | lld:lifeskim |
| pubmed-article:12393846 | lifeskim:mentions | umls-concept:C0165519 | lld:lifeskim |
| pubmed-article:12393846 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:12393846 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12393846 | pubmed:dateCreated | 2002-10-23 | lld:pubmed |
| pubmed-article:12393846 | pubmed:abstractText | In this report, we demonstrate that herpes simplex virus (HSV) infection of the cornea results in the upregulation of the matrix-degrading metalloproteinase enzyme MMP-9. This enzyme was shown to contribute to the neovascularization process that occurs in the corneal stroma in response to HSV infection. The likely source of MMP-9, at least initially after infection, was neutrophils that were signaled to invade the cornea soon after infection. Corneal infiltrating neutrophils were shown to express MMP-9, and preventing the neutrophil response with specific mAb diminished MMP-9 expression as well as the extent of angiogenesis. Further supporting a role for MMP-9 in HSV-induced corneal angiogenesis was the observation that inhibition of MMP-9 with the specific inhibitor TIMP-1 resulted in reduced angiogenesis. In addition, angiogenesis was diminished in ocularly infected MMP-9 knockout mice. Our results demonstrate that MMP-9 is involved in angiogenesis caused by HSV. Since angiogenesis appears to represent a vital step in the pathogenesis of herpetic stromal keratitis, these results indicate that targeting MMP-9 for inhibition should prove useful for the therapy of herpetic stromal keratitis. | lld:pubmed |
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| pubmed-article:12393846 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12393846 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12393846 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12393846 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12393846 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:12393846 | pubmed:author | pubmed-author:RouseBarry... | lld:pubmed |
| pubmed-article:12393846 | pubmed:author | pubmed-author:LeeSujinS | lld:pubmed |
| pubmed-article:12393846 | pubmed:author | pubmed-author:ZhengMeiM | lld:pubmed |
| pubmed-article:12393846 | pubmed:author | pubmed-author:KimBumseokB | lld:pubmed |
| pubmed-article:12393846 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12393846 | pubmed:volume | 110 | lld:pubmed |
| pubmed-article:12393846 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12393846 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12393846 | pubmed:pagination | 1105-11 | lld:pubmed |
| pubmed-article:12393846 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12393846 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12393846 | pubmed:articleTitle | Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus. | lld:pubmed |
| pubmed-article:12393846 | pubmed:affiliation | Department of Microbiology, The University of Tennessee, Knoxville, Tennessee 37996-0845, USA. | lld:pubmed |
| pubmed-article:12393846 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12393846 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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