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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2002-10-23
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pubmed:abstractText |
In this report, we demonstrate that herpes simplex virus (HSV) infection of the cornea results in the upregulation of the matrix-degrading metalloproteinase enzyme MMP-9. This enzyme was shown to contribute to the neovascularization process that occurs in the corneal stroma in response to HSV infection. The likely source of MMP-9, at least initially after infection, was neutrophils that were signaled to invade the cornea soon after infection. Corneal infiltrating neutrophils were shown to express MMP-9, and preventing the neutrophil response with specific mAb diminished MMP-9 expression as well as the extent of angiogenesis. Further supporting a role for MMP-9 in HSV-induced corneal angiogenesis was the observation that inhibition of MMP-9 with the specific inhibitor TIMP-1 resulted in reduced angiogenesis. In addition, angiogenesis was diminished in ocularly infected MMP-9 knockout mice. Our results demonstrate that MMP-9 is involved in angiogenesis caused by HSV. Since angiogenesis appears to represent a vital step in the pathogenesis of herpetic stromal keratitis, these results indicate that targeting MMP-9 for inhibition should prove useful for the therapy of herpetic stromal keratitis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-10190689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-10411111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-11001067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-11001068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-11025665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-11404367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-11549594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-11559816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-11773977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-11825017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-11888686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-1351475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-1703045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-2536829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-8551629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-8595951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-8675406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-8797002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-9013983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-9581574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-9590175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-9676913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-9727408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12393846-9791730
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1105-11
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12393846-Animals,
pubmed-meshheading:12393846-DNA,
pubmed-meshheading:12393846-Endothelial Growth Factors,
pubmed-meshheading:12393846-Female,
pubmed-meshheading:12393846-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:12393846-Keratitis, Herpetic,
pubmed-meshheading:12393846-Lymphocyte Depletion,
pubmed-meshheading:12393846-Lymphokines,
pubmed-meshheading:12393846-Matrix Metalloproteinase 9,
pubmed-meshheading:12393846-Mice,
pubmed-meshheading:12393846-Mice, Inbred BALB C,
pubmed-meshheading:12393846-Mice, Knockout,
pubmed-meshheading:12393846-Neovascularization, Pathologic,
pubmed-meshheading:12393846-Neutrophils,
pubmed-meshheading:12393846-Protease Inhibitors,
pubmed-meshheading:12393846-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:12393846-Vascular Endothelial Growth Factor A,
pubmed-meshheading:12393846-Vascular Endothelial Growth Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus.
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pubmed:affiliation |
Department of Microbiology, The University of Tennessee, Knoxville, Tennessee 37996-0845, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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