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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-2-13
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pubmed:abstractText |
Angiogenesis plays an important role in the biology of multiple myeloma (MM) and has prognostic importance in this disease. Solitary plasmacytoma is a localized plasma cell malignancy that progresses to MM in a significant number of patients. We examined if angiogenesis is increased in solitary plasmacytoma and if it can help identify patients likely to progress to myeloma. We studied angiogenesis in plasmacytoma biopsy samples and bone marrow biopsies from 25 patients. High-grade angiogenesis was present in 64% of plasmacytomas. In contrast, bone marrow angiogenesis was low in all patients. Patients with high-grade angiogenesis in the plasmacytoma sample were more likely to progress to myeloma and had a shorter progression-free survival compared with patients with low-grade angiogenesis (P =.02). Angiogenesis is increased in solitary plasmacytoma and is a significant predictor of progression to myeloma and provides further evidence of its importance in the pathogenesis of myeloma.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-4971
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pubmed:author |
pubmed-author:DispenzieriAngelaA,
pubmed-author:FonsecaRafaelR,
pubmed-author:GertzMorie AMA,
pubmed-author:GreippPhilip RPR,
pubmed-author:KumarShajiS,
pubmed-author:KyleRobert ARA,
pubmed-author:LacyMartha QMQ,
pubmed-author:LustJohn AJA,
pubmed-author:RajkumarS VincentSV,
pubmed-author:WellikLindaL,
pubmed-author:WitzigThomas ETE
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1715-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12393501-Adult,
pubmed-meshheading:12393501-Aged,
pubmed-meshheading:12393501-Aged, 80 and over,
pubmed-meshheading:12393501-Biopsy,
pubmed-meshheading:12393501-Bone Marrow,
pubmed-meshheading:12393501-Bone Neoplasms,
pubmed-meshheading:12393501-Disease Progression,
pubmed-meshheading:12393501-Disease-Free Survival,
pubmed-meshheading:12393501-Female,
pubmed-meshheading:12393501-Follow-Up Studies,
pubmed-meshheading:12393501-Humans,
pubmed-meshheading:12393501-Life Tables,
pubmed-meshheading:12393501-Male,
pubmed-meshheading:12393501-Middle Aged,
pubmed-meshheading:12393501-Multiple Myeloma,
pubmed-meshheading:12393501-Myeloma Proteins,
pubmed-meshheading:12393501-Neovascularization, Pathologic,
pubmed-meshheading:12393501-Plasmacytoma,
pubmed-meshheading:12393501-Prognosis,
pubmed-meshheading:12393501-Proportional Hazards Models,
pubmed-meshheading:12393501-Survival Analysis
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pubmed:year |
2003
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pubmed:articleTitle |
Prognostic value of angiogenesis in solitary bone plasmacytoma.
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pubmed:affiliation |
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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