| pubmed-article:12393481 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12393481 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:12393481 | lifeskim:mentions | umls-concept:C0245662 | lld:lifeskim |
| pubmed-article:12393481 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12393481 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12393481 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:12393481 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:12393481 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12393481 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12393481 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12393481 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12393481 | pubmed:dateCreated | 2003-1-31 | lld:pubmed |
| pubmed-article:12393481 | pubmed:abstractText | Dendritic cells (DCs) genetically engineered to overexpress CD95 (Fas) ligand (CD95L-DC) were proposed as tools to induce peripheral tolerance to alloantigens. Herein, we observed that CD95L-DC obtained after retroviral gene transfer in bone marrow (BM) precursors derived from CD95-deficient (lpr/lpr) mice elicit much stronger allospecific type 1 helper T-cell and cytotoxic T-cell activities than control DCs upon injection in vivo, although they induce lower T-cell responses in vitro. Indeed, a single injection of CD95L-DC prepared from C57BL/6 mice was sufficient to prime bm13 recipients for acute rejection of C57BL/6 skin allografts that were otherwise tolerated in the context of this single weak major histocompatibility complex (MHC) class I incompatibility. Massive neutrophil infiltrates depending on interleukin (IL)-1 signaling were observed at sites of CD95L-DC injection. Experiments in IL-1 receptor-deficient mice or in animals injected with depleting anti-Gr1 monoclonal antibody (mAb) established that neutrophil recruitment is required for the development of vigorous T-cell responses after injection of CD95L-DC in vivo. | lld:pubmed |
| pubmed-article:12393481 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12393481 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393481 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12393481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12393481 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12393481 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12393481 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:12393481 | pubmed:author | pubmed-author:GoldmanMichel... | lld:pubmed |
| pubmed-article:12393481 | pubmed:author | pubmed-author:Le... | lld:pubmed |
| pubmed-article:12393481 | pubmed:author | pubmed-author:FlamandVéroni... | lld:pubmed |
| pubmed-article:12393481 | pubmed:author | pubmed-author:PaulartFrédér... | lld:pubmed |
| pubmed-article:12393481 | pubmed:author | pubmed-author:BuonocoreSofi... | lld:pubmed |
| pubmed-article:12393481 | pubmed:author | pubmed-author:SalmonIsabell... | lld:pubmed |
| pubmed-article:12393481 | pubmed:author | pubmed-author:ThielemansKri... | lld:pubmed |
| pubmed-article:12393481 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:12393481 | pubmed:author | pubmed-author:BraunMichelM | lld:pubmed |
| pubmed-article:12393481 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12393481 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12393481 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:12393481 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12393481 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12393481 | pubmed:pagination | 1469-76 | lld:pubmed |
| pubmed-article:12393481 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12393481 | pubmed:meshHeading | pubmed-meshheading:12393481... | lld:pubmed |
| pubmed-article:12393481 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12393481 | pubmed:articleTitle | Dendritic cells overexpressing CD95 (Fas) ligand elicit vigorous allospecific T-cell responses in vivo. | lld:pubmed |
| pubmed-article:12393481 | pubmed:affiliation | Laboratory of Experimental Immunology, Université Libre de Bruxelles, Belgium. | lld:pubmed |
| pubmed-article:12393481 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12393481 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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