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12392746
Source:
http://linkedlifedata.com/resource/pubmed/id/12392746
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0205250
,
umls-concept:C1373060
,
umls-concept:C1533698
pubmed:issue
22
pubmed:dateCreated
2002-10-23
pubmed:abstractText
(3S,4S,5R)-2-Imino-4-methyl-5-pentyl-3-pyrrolidinol hydrochloride (1) is a potent inducible nitric oxide synthase (i-NOS) inhibitor that has three times the selectivity of its parent, (+)-cis-4-methyl-5-pentylpyrrolidin-2-imine hydrochloride (2).
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/4-methyl-5-pentylpyrrolidin-2-imine
,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Imines
,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes
,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase
,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II
,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0960-894X
pubmed:author
pubmed-author:ConnorJane RJR
,
pubmed-author:HagenTimothy JTJ
,
pubmed-author:HallinanE AnnEA
,
pubmed-author:JeromeGina MGM
,
pubmed-author:ManningPamela TPT
,
pubmed-author:MooreWilliam MWM
,
pubmed-author:PitzeleBarnett SBS
,
pubmed-author:TsymbalovSofyaS
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3337-9
pubmed:dateRevised
2011-10-27
pubmed:meshHeading
pubmed-meshheading:12392746-Enzyme Inhibitors
,
pubmed-meshheading:12392746-Humans
,
pubmed-meshheading:12392746-Imines
,
pubmed-meshheading:12392746-Inhibitory Concentration 50
,
pubmed-meshheading:12392746-Isoenzymes
,
pubmed-meshheading:12392746-Nitric Oxide Synthase
,
pubmed-meshheading:12392746-Nitric Oxide Synthase Type II
,
pubmed-meshheading:12392746-Pyrrolidines
,
pubmed-meshheading:12392746-Stereoisomerism
,
pubmed-meshheading:12392746-Structure-Activity Relationship
pubmed:year
2002
pubmed:articleTitle
3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.
pubmed:affiliation
Department of Discovery Medicinal Chemistry, Pharmacia, Skokie, IL 60077, USA.
pubmed:publicationType
Journal Article
,
Comparative Study