Source:http://linkedlifedata.com/resource/pubmed/id/12392728
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
22
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pubmed:dateCreated |
2002-10-23
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pubmed:abstractText |
In order to capture and identify key molecules that regulate the release of Ca(2+) from the sarcoplasmic reticulum (SR) of skeletal muscle, we designed specific photoaffinity probes based on the structural modification of dantrolene. Thus, GIF-0082 and GIF-0276 possessing azido- and trifluoromethyldiazirinyl-benzyl groups, respectively, at the hydantoin moiety were found to have a highly selective inhibitory effect on physiological Ca(2+) release (PCR) without affecting Ca(2+)-induced Ca(2+) release (CICR). Successful realization of the sharp discrimination between PCR and CICR has led to the creation of [(125)I]GIF-0082 and [(125)I]GIF-0276, which were synthesized by substituting a stannyl group with (125)I in the corresponding phenylstannane precursors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Dantrolene,
http://linkedlifedata.com/resource/pubmed/chemical/GIF 0082,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Relaxants, Central,
http://linkedlifedata.com/resource/pubmed/chemical/Photoaffinity Labels
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3263-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12392728-Animals,
pubmed-meshheading:12392728-Biological Transport,
pubmed-meshheading:12392728-Calcium,
pubmed-meshheading:12392728-Dantrolene,
pubmed-meshheading:12392728-Iodine Radioisotopes,
pubmed-meshheading:12392728-Mice,
pubmed-meshheading:12392728-Muscle, Skeletal,
pubmed-meshheading:12392728-Muscle Contraction,
pubmed-meshheading:12392728-Muscle Relaxants, Central,
pubmed-meshheading:12392728-Photoaffinity Labels,
pubmed-meshheading:12392728-Sarcoplasmic Reticulum
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pubmed:year |
2002
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pubmed:articleTitle |
[(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscle.
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pubmed:affiliation |
Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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