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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2002-10-23
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pubmed:abstractText |
Human butyrylcholinesterase is the enzyme responsible of mivacurium and succinylcholine metabolism, which may be significantly impaired when mutation Asp70Gly is found in patients. We describe a simple PCR method for the detection of this variant. Thirteen out of sixteen patients tested after prolonged apnea were positive for the presence of this mutation (50.0% homozygotes and 31.3% heterozygotes), suggesting that this test contributes to the explanation of some clinical events and to their prevention in relatives of these patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1434-6621
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
799-801
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12392308-Apnea,
pubmed-meshheading:12392308-Butyrylcholinesterase,
pubmed-meshheading:12392308-Female,
pubmed-meshheading:12392308-Genetic Testing,
pubmed-meshheading:12392308-Genetic Variation,
pubmed-meshheading:12392308-Heterozygote,
pubmed-meshheading:12392308-Homozygote,
pubmed-meshheading:12392308-Humans,
pubmed-meshheading:12392308-Isoquinolines,
pubmed-meshheading:12392308-Male,
pubmed-meshheading:12392308-Pharmacogenetics,
pubmed-meshheading:12392308-Point Mutation,
pubmed-meshheading:12392308-Polymerase Chain Reaction,
pubmed-meshheading:12392308-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:12392308-Succinylcholine
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pubmed:year |
2002
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pubmed:articleTitle |
Rapid identification of atypical variant of plasma butyrylcholinesterase by PCR.
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pubmed:affiliation |
Laboratoire de Biochimie, Toxicologie, et Pharmacologie cliniques, H?pital d'Instruction des Armées Bégin, Saint Mandé, France. hiabegin.biochimie@worldonline.fr
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pubmed:publicationType |
Journal Article
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