Linked Life Data

12391194

Source:http://linkedlifedata.com/resource/pubmed/id/12391194

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12391194rdf:typepubmed:Citationlld:pubmed
pubmed-article:12391194lifeskim:mentionsumls-concept:C0001688lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C1333899lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C0039195lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C0019728lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C0030956lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C0070099lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C0879626lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C0443146lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C0871261lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C2911692lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C1706817lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C1533691lld:lifeskim
pubmed-article:12391194lifeskim:mentionsumls-concept:C1515655lld:lifeskim
pubmed-article:12391194pubmed:issue9lld:pubmed
pubmed-article:12391194pubmed:dateCreated2002-10-22lld:pubmed
pubmed-article:12391194pubmed:abstractTextParathyroid hormone-related protein (PTH-rP), a protein produced by prostate carcinoma and other epithelial cancers, is a key agent in the development of bone metastases. We investigated whether the protein follows the self-tolerance paradigm or can be used as a target Ag for anticancer immunotherapy by investigating the immunogenicity of two HLA-A(*)02.01-binding PTH-rP-derived peptides (PTR-2 and -4) with different affinity qualities. PTH-rP peptide-specific CTL lines were generated from the PBMC of two HLA-A(*)02.01(+) healthy individuals, stimulated in vitro with PTH-rP peptide-loaded autologous dendritic cells and IL-2. The peptide-specific CTLs were able to kill PTH-rP(+)HLA-A(*)02.01(+) breast and prostate carcinoma cell lines. The two peptides were also able to elicit a strong antitumor PTH-rP-specific CTL response in HLA-A(*)02.01 (HHD) transgenic mice. The vaccinated mice did not show any sign of side effects due to cell-mediated autoimmunity or toxicity. In this study we describe two immunogenic and toxic-free PTH-rP peptides as valid candidates for the design of peptide-based vaccination strategies against prostate cancer and bone metastases from the most common epithelial malignancies.lld:pubmed
pubmed-article:12391194pubmed:languageenglld:pubmed
pubmed-article:12391194pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12391194pubmed:citationSubsetAIMlld:pubmed
pubmed-article:12391194pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12391194pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12391194pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12391194pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12391194pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12391194pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12391194pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12391194pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12391194pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12391194pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12391194pubmed:statusMEDLINElld:pubmed
pubmed-article:12391194pubmed:monthNovlld:pubmed
pubmed-article:12391194pubmed:issn0022-1767lld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:LozziLuisaLlld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:LemonnierFran...lld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:NeriPaoloPlld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:ScardinoAnton...lld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:Kosmatopoulos...lld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:CusiMaria...lld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:FranciniGuido...lld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:PetrioliRober...lld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:PozzessereDan...lld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:CorrealePierp...lld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:SabatinoMaria...lld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:CampocciaGius...lld:pubmed
pubmed-article:12391194pubmed:authorpubmed-author:FanettiGiusep...lld:pubmed
pubmed-article:12391194pubmed:issnTypePrintlld:pubmed
pubmed-article:12391194pubmed:day1lld:pubmed
pubmed-article:12391194pubmed:volume169lld:pubmed
pubmed-article:12391194pubmed:ownerNLMlld:pubmed
pubmed-article:12391194pubmed:authorsCompleteYlld:pubmed
pubmed-article:12391194pubmed:pagination4840-9lld:pubmed
pubmed-article:12391194pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:meshHeadingpubmed-meshheading:12391194...lld:pubmed
pubmed-article:12391194pubmed:year2002lld:pubmed
pubmed-article:12391194pubmed:articleTitleHigh-affinity HLA-A(*)02.01 peptides from parathyroid hormone-related protein generate in vitro and in vivo antitumor CTL response without autoimmune side effects.lld:pubmed
pubmed-article:12391194pubmed:affiliationDivision of Medical Oncology, Institut National de la Santé et de la Recherche Médicale Unité d'Immunité Cellulaire Antivirale, Institut Pasteur, Paris, France. francini@unisi.itlld:pubmed
pubmed-article:12391194pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12391194pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:5744entrezgene:pubmedpubmed-article:12391194lld:entrezgene
http://linkedlifedata.com/r...entrezgene:pubmedpubmed-article:12391194lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12391194lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12391194lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12391194lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12391194lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12391194lld:pubmed