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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2002-10-22
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pubmed:abstractText |
Histone deacetylase 1 (HDAC1) is a major regulator of chromatin structure and gene expression. Tight control of HDAC1 expression is essential for normal cell cycle progression of mammalian cells. HDAC1 mRNA levels are regulated by growth factors and by changes in intracellular deacetylase activity levels. Stimulation of the mitogen-activated protein kinase cascade by anisomycin or growth factors, together with inhibition of deacetylases by trichostatin A (TSA), leads to stable histone H3 phosphoacetylation and strongly induced HDAC1 expression. In contrast, activation of the nucleosomal response by anisomycin alone results only in transient phosphoacetylation of histone H3 without affecting HDAC1 mRNA levels. The transcriptional induction of the HDAC1 gene by anisomycin and TSA is efficiently blocked by H89, an inhibitor of the nucleosomal response. Detailed studies of the kinetics of histone acetylation and phosphorylation show that the two modifications are synergistic and essential for induced HDAC1 transcription. Activation of the HDAC1 gene by anisomycin together with TSA or by growth factors is accompanied by phosphoacetylation of HDAC1 promoter-associated histone H3. Our results present evidence for a precise regulatory mechanism which allows induction of the HDAC1 gene in response to proliferation signals and modulation of HDAC1 expression dependent on intracellular deacetylase levels.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10207071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10436156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10441074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10455166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10469656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10615135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10638745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10694882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10825229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10888872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10888886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-10899125,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-9271381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-9464271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-9571167,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12391151-9891014
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anisomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/HDAC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleosomes,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/trichostatin A
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7820-30
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12391151-Animals,
pubmed-meshheading:12391151-Mice,
pubmed-meshheading:12391151-Phosphorylation,
pubmed-meshheading:12391151-Hydroxamic Acids,
pubmed-meshheading:12391151-Histones,
pubmed-meshheading:12391151-Enzyme Inhibitors,
pubmed-meshheading:12391151-Growth Substances,
pubmed-meshheading:12391151-RNA, Messenger,
pubmed-meshheading:12391151-Enzyme Activation,
pubmed-meshheading:12391151-Protein Synthesis Inhibitors,
pubmed-meshheading:12391151-Acetylation,
pubmed-meshheading:12391151-3T3 Cells,
pubmed-meshheading:12391151-Gene Expression Regulation,
pubmed-meshheading:12391151-Nucleosomes,
pubmed-meshheading:12391151-Promoter Regions, Genetic,
pubmed-meshheading:12391151-Histone Deacetylases
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