Linked Life Data

12389996

Source:http://linkedlifedata.com/resource/pubmed/id/12389996

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2002-10-22
pubmed:abstractText
Carcinoid tumor of the appendix is an endocrine tumor that is histologically similar to, but biologically less aggressive than carcinoids arising from other parts of the gastrointestinal tract. In this study, we examined E-cadherin, beta-catenin, DCC, p53 and Ki67 immunoexpression in cases of carcinoid of the appendix and made a comparison with non-appendiceal carcinoid tumors. Nine cases of appendiceal carcinoid and 11 biopsies of carcinoid of other parts of the gastrointestinal tract, five cases of the small intestine and six of the stomach were immunohistochemically evaluated for Ki67, p53, DCC, E-cadherin and beta-catenin. Two main patterns of beta-catenin staining were observed. The first pattern was characterized as membranous and cytoplasmic, and was seen mainly in the peripheral cells of the nests. The second pattern was diffuse, predominantly membranous. Most (five of seven) appendiceal carcinoids and only three of 11 non-appendiceal cases showed the first staining pattern (p < 0.05). Immunoexpression of E-cadherin and DCC was similar in both groups. p53 and Ki-67 immunostaining revealed stronger nuclear positivity in the non-appendiceal carcinoid tumors (statistically not significant). We found a pattern of beta-catenin immunostaining in typical carcinoid tumors of the appendix that was different from the pattern seen in non-appendiceal carcinoid tumors. This alteration suggests that carcinoid of the appendix may represent a different subtype of carcinoid tumors with different immunohistochemical and biological behavior.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0344-0338
pubmed:author
pubmed:issnType
Print
pubmed:volume
198
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
531-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12389996-Adult, pubmed-meshheading:12389996-Aged, pubmed-meshheading:12389996-Aged, 80 and over, pubmed-meshheading:12389996-Appendix, pubmed-meshheading:12389996-Cadherins, pubmed-meshheading:12389996-Carcinoid Tumor, pubmed-meshheading:12389996-Cecal Neoplasms, pubmed-meshheading:12389996-Cell Adhesion Molecules, pubmed-meshheading:12389996-Cytoskeletal Proteins, pubmed-meshheading:12389996-Female, pubmed-meshheading:12389996-Gastrointestinal Neoplasms, pubmed-meshheading:12389996-Humans, pubmed-meshheading:12389996-Immunohistochemistry, pubmed-meshheading:12389996-Ki-67 Antigen, pubmed-meshheading:12389996-Male, pubmed-meshheading:12389996-Middle Aged, pubmed-meshheading:12389996-Receptors, Cell Surface, pubmed-meshheading:12389996-Trans-Activators, pubmed-meshheading:12389996-Tumor Suppressor Protein p53, pubmed-meshheading:12389996-Tumor Suppressor Proteins, pubmed-meshheading:12389996-beta Catenin
pubmed:year
2002
pubmed:articleTitle
Different beta-catenin immunoexpression in carcinoid tumors of the appendix in comparison to other gastrointestinal carcinoid tumors.
pubmed:affiliation
Department of Pathology, The Chaim Sheba Medical Center, Tel-Hashomer, Israel.
pubmed:publicationType
Journal Article, Comparative Study