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rdf:type |
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lifeskim:mentions |
umls-concept:C0039062,
umls-concept:C0271510,
umls-concept:C0439662,
umls-concept:C0449774,
umls-concept:C1326152,
umls-concept:C1335962,
umls-concept:C1421567,
umls-concept:C1522492,
umls-concept:C1527940,
umls-concept:C1705831,
umls-concept:C2587213
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pubmed:issue |
4
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pubmed:dateCreated |
2002-10-21
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pubmed:abstractText |
Recognition by T cells of their ligands at the surface of antigen-presenting cells (APCs) leads to T cell activation, polarization of the T cell toward the APC, and formation of an immune synapse. Using ZAP-70-deficient T cells expressing zeta-GFP, we show that ZAP-70 signaling drives the TCR-dependent reorientation of the microtubule-organizing center thus leading to relocation of a zeta-GFP(+) intracellular compartment close to the APC. ZAP-70 is also necessary to supply the synapse with the signaling molecules PKC-theta and LAT. In contrast, ZAP-70 is not required for clustering of zeta-GFP and CD2 or exclusion of CD45 and CD43 from the synapse. These data show that ZAP-70-dependent signaling is required for formation of a functional immune synapse.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD43,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/LAT protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PRKCQ protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/UN1 sialoglycoprotein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP-70 Protein-Tyrosine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP70 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/antigen T cell receptor, zeta chain
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1074-7613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
389-99
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pubmed:dateRevised |
2011-9-7
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pubmed:meshHeading |
pubmed-meshheading:12387734-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12387734-Antigen-Presenting Cells,
pubmed-meshheading:12387734-Antigens, CD,
pubmed-meshheading:12387734-Antigens, CD2,
pubmed-meshheading:12387734-Antigens, CD43,
pubmed-meshheading:12387734-Antigens, CD45,
pubmed-meshheading:12387734-Carrier Proteins,
pubmed-meshheading:12387734-Cell Communication,
pubmed-meshheading:12387734-Cell Line,
pubmed-meshheading:12387734-Cell Polarity,
pubmed-meshheading:12387734-Green Fluorescent Proteins,
pubmed-meshheading:12387734-Humans,
pubmed-meshheading:12387734-Intercellular Junctions,
pubmed-meshheading:12387734-Isoenzymes,
pubmed-meshheading:12387734-Jurkat Cells,
pubmed-meshheading:12387734-Luminescent Proteins,
pubmed-meshheading:12387734-Lymphocyte Activation,
pubmed-meshheading:12387734-Membrane Proteins,
pubmed-meshheading:12387734-Microtubule-Organizing Center,
pubmed-meshheading:12387734-Phosphoproteins,
pubmed-meshheading:12387734-Protein Kinase C,
pubmed-meshheading:12387734-Protein-Tyrosine Kinases,
pubmed-meshheading:12387734-Receptors, Antigen, T-Cell,
pubmed-meshheading:12387734-Recombinant Fusion Proteins,
pubmed-meshheading:12387734-Sialoglycoproteins,
pubmed-meshheading:12387734-Signal Transduction,
pubmed-meshheading:12387734-T-Lymphocytes,
pubmed-meshheading:12387734-ZAP-70 Protein-Tyrosine Kinase
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pubmed:year |
2002
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pubmed:articleTitle |
In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern.
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pubmed:affiliation |
INSERM U520, Institut Curie, 12 Rue Lhomond, 75005 Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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