Linked Life Data

12387581

Source:http://linkedlifedata.com/resource/pubmed/id/12387581

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-10-21
pubmed:abstractText
Diurnal variation in serum cortisol is nearly always absent in patients with Cushing's syndrome (CS), as shown by elevated levels of midnight serum cortisol (MSC). The sensitivity of MSC in the diagnosis of CS has been shown to be 96-100% measured on an inpatient basis. The purpose of this study was to state reference values for MSC measured on an outpatient basis in healthy non-sleeping controls, and to calculate the sensitivity and specificity of the test in patients with verified CS based on these data. Thirty-six healthy volunteers (11 males, 25 females) with a median age of 40.5 (range 22-60) years and a mean body mass index (BMI) of 27.0+/-5.9kg/m2 were included in the study. Serum cortisol was measured at 24.00h. In 35 CS patients (5 males, 30 females) with a median age of 44.5 (range 23-79) years and mean BMI of 28.5+/-6.9 kg/m2, MSC was measured on the first night after admission to hospital, in a non-sleeping state. All controls, with the exception of one, had MSC values below 200nmol/L. One CS patient showed an MSC level below 200nmol/L. Based on these observations, the sensitivity and specificity of the test were 97.1% and 97.2%, respectively, when 200nmol/L was used as the cut-off limit. Non-sleeping state does not seem to compromise the sensitivity or the specificity of the test.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0036-5513
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
357-60
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Midnight serum cortisol: comparison of healthy volunteers and hospitalized patients with Cushing's syndrome.
pubmed:affiliation
Department of Internal Medicine, Helsinki University Central Hospital, Finland. laura.pikkarainen@hus.fi
pubmed:publicationType
Journal Article, Comparative Study