Source:http://linkedlifedata.com/resource/pubmed/id/12386291
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2002-10-18
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| pubmed:abstractText |
Hepatocyte growth factor (HGF) has mitogenic, morphogenic and anti-apoptotic activities on renal epithelial cells, and is a potential renotropin for renal regeneration. In chronic renal failure/fibrosis, HGF in the kidney declines in a manner reciprocal to the increase in transforming growth factor-beta (TGF-beta). Neutralization of HGF by the antibody leads to acceleration of renal failure/fibrosis, while HGF administration leads to remarkable attenuation, thus indicating the importance of the balance between HGF and TGF-beta in the pathogenesis and therapy of chronic renal failure. HGF is strongly considered as potential treatment for acute and chronic renal failure.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0931-0509
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
17 Suppl 9
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
59-61
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:12386291-Animals,
pubmed-meshheading:12386291-Hepatocyte Growth Factor,
pubmed-meshheading:12386291-Humans,
pubmed-meshheading:12386291-Kidney,
pubmed-meshheading:12386291-Mitogens,
pubmed-meshheading:12386291-Renal Insufficiency,
pubmed-meshheading:12386291-Transforming Growth Factor beta
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Renotropic role and therapeutic potential of HGF in the kidney.
|
| pubmed:affiliation |
Division of Molecular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
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| pubmed:publicationType |
Journal Article
|