Linked Life Data

12385815

Source:http://linkedlifedata.com/resource/pubmed/id/12385815

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-10-18
pubmed:abstractText
We investigated the effects of Nerve Growth Factor (NGF) administration on the maturation of reactivity to spatial and non-spatial novelty in developing mice. CD-1 mice of both sexes received intracerebral administration of NGF on postnatal day (pnd) 15, and their response to object displacement (spatial novelty) and object substitution (object novelty) were assessed in a spatial open-field with four objects on pnd 18 or 28. On pnd 18, NGF induced only in males precocious appearance of spatial novelty discrimination, while increasing choline acetyltransferase activity in neocortex and hippocampus of both sexes. The behavioral and neurochemical effects disappeared by pnd 28. NGF triggers adult-like responding to spatial novelty in developing mice and such effect is gender-specific.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0166-4328
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
289-98
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
NGF induces appearance of adult-like response to spatial novelty in 18-day male mice.
pubmed:affiliation
Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e Sistema, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. gemma.calamandrei@iss.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't