Linked Life Data

12385667

Source:http://linkedlifedata.com/resource/pubmed/id/12385667

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2002-10-18
pubmed:abstractText
Determination of the sequence of the human genome has been a major undertaking. It provided powerful tools to explore the genetic component in complex diseases. To fully understand the genetic pathways contributing to complex disease traits, we must not only reveal the genomic locus of all genes involved, but also delineate the functionally relevant allelic variation in such genes and understand the patterns of gene expression leading up to the actual disease trait. Insight in the genetic contribution to clinical endpoints of complex disease and their biological risk factors, therefore, requires an understanding of both the structure and the biology of the genome. This paper constitutes a tutorial overview of the organisation of the human genome, the tools it provides for molecular genetic studies, and the genomic background of the current strategies for gene identification.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0301-0511
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-31
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Organisation of the human genome and our tools for identifying disease genes.
pubmed:affiliation
Section Molecular Epidemiology, Sylvius Laboratory, Leiden University Medical Centre, PO Box 9503, 2300 RA Leiden, The Netherlands. p.slagboom@lumc.nl
pubmed:publicationType
Journal Article, Review