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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2002-10-17
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pubmed:abstractText |
The aberrant expression of c-myb in leukemic cells suggests that c-myb may play an important role in leukemogenesis. Therefore, disrupting c-myb function might provide a strategy for controlling leukemic cell growth. Use of dominant negative mutants as a strategy for inhibiting oncogene function has attracted considerable attention. The aim of this study was to induce apoptosis in K562 cells by dominant negative c-myb (DN-myb).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0301-472X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1139-46
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12384144-3T3 Cells,
pubmed-meshheading:12384144-Animals,
pubmed-meshheading:12384144-Apoptosis,
pubmed-meshheading:12384144-Cell Nucleus,
pubmed-meshheading:12384144-Cell Survival,
pubmed-meshheading:12384144-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:12384144-DNA Fragmentation,
pubmed-meshheading:12384144-DNA Primers,
pubmed-meshheading:12384144-Gene Deletion,
pubmed-meshheading:12384144-Genes, Dominant,
pubmed-meshheading:12384144-Genes, Reporter,
pubmed-meshheading:12384144-Genes, myb,
pubmed-meshheading:12384144-Genetic Vectors,
pubmed-meshheading:12384144-Humans,
pubmed-meshheading:12384144-K562 Cells,
pubmed-meshheading:12384144-Mice,
pubmed-meshheading:12384144-Polymerase Chain Reaction,
pubmed-meshheading:12384144-Promoter Regions, Genetic,
pubmed-meshheading:12384144-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:12384144-Transfection
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pubmed:year |
2002
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pubmed:articleTitle |
Induction of apoptosis in K562 cells by dominant negative c-myb.
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pubmed:affiliation |
Department of Pediatrics, Chonbuk National University Medical School, Jeonju, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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