|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5-6
|
|
pubmed:dateCreated |
2002-10-16
|
|
pubmed:abstractText |
Homozygous adenine phosphoribosyltransferase (APRT) deficiency is associated with 2,8-dihydroxyadenine (DHA) nephrolithiasis. Using whole kidney RNA from Aprt knockout mice, we previously showed that the renal deposition of DHA leads to changes in the expression of genes involved in tissue injury. To determine the cellular basis for these changes, we investigated gene expression in cultured human kidney (NHK-C) and African green monkey (BSC-1) epithelial cells exposed to DHA or calcium oxalate monohydrate (COM) crystals.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,8-dihydroxyadenine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenine,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Oxalate,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha3,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin beta Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-sis,
http://linkedlifedata.com/resource/pubmed/chemical/alpha Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/integrin beta6
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1018-7782
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2002 S. Karger AG, Basel
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
365-73
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:12381921-Adenine,
pubmed-meshheading:12381921-Animals,
pubmed-meshheading:12381921-Calcium Oxalate,
pubmed-meshheading:12381921-Cell Line,
pubmed-meshheading:12381921-Cercopithecus aethiops,
pubmed-meshheading:12381921-Crystallization,
pubmed-meshheading:12381921-Cytoskeletal Proteins,
pubmed-meshheading:12381921-DNA, Complementary,
pubmed-meshheading:12381921-Dogs,
pubmed-meshheading:12381921-Epithelial Cells,
pubmed-meshheading:12381921-Gene Expression Regulation,
pubmed-meshheading:12381921-Humans,
pubmed-meshheading:12381921-Integrin alpha3,
pubmed-meshheading:12381921-Integrin beta Chains,
pubmed-meshheading:12381921-Kidney,
pubmed-meshheading:12381921-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:12381921-Proto-Oncogene Proteins c-sis,
pubmed-meshheading:12381921-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12381921-alpha Catenin
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Induction of alpha-catenin, integrin alpha3, integrin beta6, and PDGF-B by 2,8-dihydroxyadenine crystals in cultured kidney epithelial cells.
|
|
pubmed:affiliation |
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Ind, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
