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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2002-10-14
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pubmed:abstractText |
Interleukin (IL)-12, especially in the presence of neutralizing anti-IL-4 monoclonal antibodies, primed CD45RO(-) T clones for high CCL3/macrophage-inflammatory protein-1alpha (MIP-1alpha) and CCL4/MIP-1beta levels. In CD4(+) and CD8(+) clones from two patients deficient for IL-12Rbeta1 (IL-12Rbeta1(-/-)), production of CCL3/MIP-1alpha and CCL4/MIP-1beta was defective. CD4(+) clones from two patients deficient for interferon-gamma (IFN-gamma) R1 (IFN-gammaR1(-/-)) produced somewhat decreased CCL4/MIP-1beta levels. IL-12 failed to prime CD4(+) or CD8(+) healthy clones for high CCL5/regulated on activation, normal T expressed and secreted (RANTES) production, although its secretion was impaired in CD4(+) clones from IL-12Rbeta1(-/-) and IFN-gammaR1(-/-) patients. CCR5 surface expression was up-regulated in resting peripheral blood mononuclear cells and CD4(+) clones from both kinds of patients, rendering them more susceptible to CCR5-dependent (R5) HIV-1 infection. Neutralization of IFN-gamma increased CCR5 expression and decreased CC-chemokine secretion by CD4(+) clones from healthy and IL-12Rbeta1(-/-) individuals, suggesting an IFN-gamma-dependent control of CCR5 expression. These data provide the first documented analysis of chemokine secretion and chemokine receptor expression on T cells from IL-12 and IFN-gamma receptor-deficient patients and dissect the role of IL-12 and IFN-gamma on inducing inflammatory chemokine secretion and down-regulating CCR5 expression in human T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL3,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL4,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL5,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/interferon gamma receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0741-5400
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pubmed:author |
pubmed-author:AltareFredericF,
pubmed-author:BorghiIgorI,
pubmed-author:BovolentaChiaraC,
pubmed-author:CasanovaJean-LaurentJL,
pubmed-author:ForniGuidoG,
pubmed-author:GerosaFrancaF,
pubmed-author:JouanguyEmmanuelleE,
pubmed-author:LosanaGiulianaG,
pubmed-author:MengozziManuelaM,
pubmed-author:NovelliFrancescoF,
pubmed-author:PoliGuidoG,
pubmed-author:RigamontiLauraL,
pubmed-author:SherryBarbaraB,
pubmed-author:TrinchieriGiorgioG
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
735-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12377943-Antigens, CD4,
pubmed-meshheading:12377943-Antigens, CD45,
pubmed-meshheading:12377943-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12377943-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12377943-Cells, Cultured,
pubmed-meshheading:12377943-Chemokine CCL3,
pubmed-meshheading:12377943-Chemokine CCL4,
pubmed-meshheading:12377943-Chemokine CCL5,
pubmed-meshheading:12377943-Chemokines, CC,
pubmed-meshheading:12377943-Down-Regulation,
pubmed-meshheading:12377943-Gene Expression,
pubmed-meshheading:12377943-HIV Infections,
pubmed-meshheading:12377943-HIV-1,
pubmed-meshheading:12377943-Humans,
pubmed-meshheading:12377943-Interferon-gamma,
pubmed-meshheading:12377943-Interleukin-12,
pubmed-meshheading:12377943-Interleukin-4,
pubmed-meshheading:12377943-Macrophage Inflammatory Proteins,
pubmed-meshheading:12377943-Receptors, CCR5,
pubmed-meshheading:12377943-Receptors, Interferon,
pubmed-meshheading:12377943-Receptors, Interleukin,
pubmed-meshheading:12377943-Receptors, Interleukin-12,
pubmed-meshheading:12377943-Virus Replication
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pubmed:year |
2002
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pubmed:articleTitle |
IFN-gamma and IL-12 differentially regulate CC-chemokine secretion and CCR5 expression in human T lymphocytes.
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pubmed:affiliation |
Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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