Linked Life Data

12376156

Source:http://linkedlifedata.com/resource/pubmed/id/12376156

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-10-11
pubmed:abstractText
Previous reports from our laboratory have provided evidence that acute, i.e., concurrent, treatment with selective serotonin reuptake inhibitors (SSRIs) augments the stimulus effects of indoleamine and phenethylamine hallucinogens in the rat. In the present investigation, the acute effects of fluoxetine and citalopram on stimulus control induced by (-)-2,5-dimethoxy-4-methylamphetamine (DOM) were compared with those following subchronic, i.e., 10-day treatment with the SSRIs. Stimulus control was established using DOM (0.56 mg/kg; 75-min pretreatment time) in a group of 11 rats. A two-lever, fixed ratio 10, positively reinforced task with saline controls was employed. The effects of a range of doses of DOM when given alone were compared with those following both acute and subchronic pretreatment with fluoxetine and citalopram in combination with DOM. It was found that acute administration of fluoxetine and citalopram potentiated the stimulus effects of DOM. Furthermore, it was observed that the degree of potentiation was not diminished by treatment with either fluoxetine or citalopram for a period of 10 days. It is concluded that whatever adaptive changes may take place in response to a 10-day period of treatment with either citalopram or fluoxetine, these adaptations are independent of the mechanisms responsible for the potentiation of the stimulus effects of DOM by the SSRIs.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
95-101
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:12376156-2,5-Dimethoxy-4-Methylamphetamine, pubmed-meshheading:12376156-Animals, pubmed-meshheading:12376156-Behavior, Animal, pubmed-meshheading:12376156-Citalopram, pubmed-meshheading:12376156-Conditioning, Operant, pubmed-meshheading:12376156-Dose-Response Relationship, Drug, pubmed-meshheading:12376156-Drug Interactions, pubmed-meshheading:12376156-Fluoxetine, pubmed-meshheading:12376156-Male, pubmed-meshheading:12376156-Rats, pubmed-meshheading:12376156-Rats, Inbred F344, pubmed-meshheading:12376156-Receptors, Serotonin, pubmed-meshheading:12376156-Receptors, Serotonin, 5-HT1, pubmed-meshheading:12376156-Serotonin Receptor Agonists, pubmed-meshheading:12376156-Serotonin Uptake Inhibitors, pubmed-meshheading:12376156-Stimulation, Chemical, pubmed-meshheading:12376156-Time Factors
pubmed:year
2002
pubmed:articleTitle
The effects of acute and subchronic treatment with fluoxetine and citalopram on stimulus control by DOM.
pubmed:affiliation
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 102 Farber Hall, Buffalo, NY 14214-3000, USA. jcwinter@acsu.buffalo.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't