Source:http://linkedlifedata.com/resource/pubmed/id/12375037
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2002-10-10
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| pubmed:abstractText |
In the present study, we examined the proportions of Epstein-Barr virus-associated gastric carcinomas (EBV-GCs) in Guangzhou, southern China and Shenyang, northern China, two areas differing markedly in nasopharyngeal carcinoma (NPC) incidence. Using in situ hybridization assay, the presence of EBV-encoded small RNA (EBER) was examined in 198, and 180 gastric cancer cases in Guangzhou and Shenyang, respectively. The proportion of EBV-GC in Guangzhou (9%) was significantly higher than that in Shenyang (6%), and the odds ratio (OR) for Guangzhou, after adjusting for the effects of age, sex, and tumor subsite, was 2.7 (95% CI = 1.1-6.2) when Shenyang was taken as reference. There was a male predominance of EBV-GC, and the OR for male was 3.0 (95% CI = 1.2-7.3) when female was taken as reference. We observed a weak and negative age dependence in the proportion of EBV-GC (p-values for trend = 0.077). The EBV-GC was most commonly observed in the middle part of stomach in both series. The frequency of EBV-GCs was higher in cases with p53 overexpression than in cases without p53 expression (OR = 2.4, 95% CI = 1.0-5.8). Among p53-positive cases, the frequency of EBV-GC decreased as the proportion of p53-positive carcinoma cells increased (p for trend = 0.021). In conclusion, the present study suggested that the frequency of EBV-GC in Guangzhou, southern China, where NPC is the most common in the world, may be higher than that in other parts of China.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epstein-Barr virus encoded RNA 1,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotide Probes,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1021-335X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
9
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1293-8
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12375037-Adult,
pubmed-meshheading:12375037-Aged,
pubmed-meshheading:12375037-Aged, 80 and over,
pubmed-meshheading:12375037-China,
pubmed-meshheading:12375037-Epstein-Barr Virus Infections,
pubmed-meshheading:12375037-Female,
pubmed-meshheading:12375037-Gene Expression,
pubmed-meshheading:12375037-Herpesvirus 4, Human,
pubmed-meshheading:12375037-Humans,
pubmed-meshheading:12375037-Immunoenzyme Techniques,
pubmed-meshheading:12375037-In Situ Hybridization,
pubmed-meshheading:12375037-Male,
pubmed-meshheading:12375037-Middle Aged,
pubmed-meshheading:12375037-Oligonucleotide Probes,
pubmed-meshheading:12375037-Prognosis,
pubmed-meshheading:12375037-RNA, Viral,
pubmed-meshheading:12375037-Stomach Neoplasms,
pubmed-meshheading:12375037-Tumor Suppressor Protein p53
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| pubmed:articleTitle |
The Epstein-Barr virus-associated gastric carcinoma in Southern and Northern China.
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| pubmed:affiliation |
Department of Pathology, the Second Affiliated Hospital, Guangzhou Medical College, Haizhu District, Guagngzhou 510260, GD, Guangdong, P.R. China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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