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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0001625,
umls-concept:C0019932,
umls-concept:C0023884,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0036679,
umls-concept:C0045044,
umls-concept:C0237868,
umls-concept:C0376315,
umls-concept:C0392756,
umls-concept:C0870883,
umls-concept:C1720784,
umls-concept:C1880022,
umls-concept:C2745955
|
| pubmed:dateCreated |
1976-2-2
|
| pubmed:abstractText |
In order to study the metabolism of 18-OH-11-deoxycorticosterone, the mineralocorticoid hormone responsible for hypertension in rats and humans, we have synthesized the following dihydrogenated and tetrahydrogenated reference derivatives: 18,21-dihydroxy-5alpha-pregnane-3,20-dione, 18,21-dihydroxy-5beta-pregnane-3,20-dione, 3alpha,18,21-trihydroxy-5alpha-pregnan-20-one (I), 3beta,18,21-trihydroxy-5alpha-pregnan-20-one (II), 3alpha,18,21-trihydroxy-5beta-pregnan-20-one (III) and 3beta,18,21-trihydroxy-5beta-pregnan-20-one (IV). A complete separation of these compounds from each other and from tetrahydrocorticosterone isomers has been realized only by the association of thin-layer chromatography and gas-liquid chromatography on high-efficiency glass capillary columns. Characterization by gas-liquid chromatography-mas spectrometry is described. The stereoisomer distribution in rats is: adrenals of adult males and females (compounds I and II in the ratio 4:1); adrenals of 23-day-old males and females (compounds I, II and III, 11:11:3); liver of females (compound I and traces of III); and the liver of adult male (compounds II, III and IV, 4.5:4.5:1).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0021-9673
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
29
|
| pubmed:volume |
112
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
617-30
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1237495-18-Hydroxydesoxycorticosterone,
pubmed-meshheading:1237495-Adrenal Glands,
pubmed-meshheading:1237495-Adult,
pubmed-meshheading:1237495-Animals,
pubmed-meshheading:1237495-Chromatography, Gas,
pubmed-meshheading:1237495-Chromatography, High Pressure Liquid,
pubmed-meshheading:1237495-Desoxycorticosterone,
pubmed-meshheading:1237495-Female,
pubmed-meshheading:1237495-Gas Chromatography-Mass Spectrometry,
pubmed-meshheading:1237495-Humans,
pubmed-meshheading:1237495-Hypertension,
pubmed-meshheading:1237495-Isomerism,
pubmed-meshheading:1237495-Liver,
pubmed-meshheading:1237495-Male,
pubmed-meshheading:1237495-Mass Spectrometry,
pubmed-meshheading:1237495-Oxidation-Reduction,
pubmed-meshheading:1237495-Rats,
pubmed-meshheading:1237495-Stereoisomerism
|
| pubmed:year |
1975
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| pubmed:articleTitle |
Separation and characterization of the reduced metabolites of the 18-hydroxydeoxycorticosterone hormone by gas-liquid chromatography-mass spectrometry. Occurrence of stereoisomeric forms in rat adrenals and liver.
|
| pubmed:publicationType |
Journal Article
|