Linked Life Data

12374899

Source:http://linkedlifedata.com/resource/pubmed/id/12374899

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2002-10-10
pubmed:abstractText
Troglitazone increased cardiac output and stroke volume, as a result of decreased peripheral resistance, in diabetic patients with normal cardiac function. The cardiovascular effects of troglitazone in patients with heart failure are unknown. The aim of the study was to evaluate the cardiovascular effects of troglitazone in patients with heart failure. Blood pressure and echocardiographic findings were evaluated before and 1, 2, 3 and 4 hours after a single dose of troglitazone (400 mg) or placebo, in eight type II diabetic patients with congestive heart failure. The plasma catecholamines and coefficient of variance of RR intervals (CVRR) were also measured. Neither heart rate nor blood pressure changed after the administration of troglitazone. Left ventricular (LV) end-diastolic dimension did not change either, however, the LV end-systolic dimension significantly decreased compared with its baseline value and with that of the placebo group. On the other hand, the % fractional shortening and the E/A ratio increased significantly after troglitazone. The LV end-diastolic volume did not change, whereas the LV end-systolic volume significantly decreased. The stroke volume and the LV ejection fraction significantly increased compared with its baseline value and with that of the placebo group. The peripheral vascular resistance did not change after the administration of troglitazone, whereas plasma catecholamines significantly decreased, and CVRR remained unchanged in both groups. These hemodynamic changes suggest that a single oral dose of troglitazone induced inotropy without activation of the sympathetic nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0920-3206
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-20
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:12374899-Blood Pressure, pubmed-meshheading:12374899-Cardiac Output, pubmed-meshheading:12374899-Catecholamines, pubmed-meshheading:12374899-Chromans, pubmed-meshheading:12374899-Cross-Over Studies, pubmed-meshheading:12374899-Diabetes Mellitus, Type 2, pubmed-meshheading:12374899-Double-Blind Method, pubmed-meshheading:12374899-Female, pubmed-meshheading:12374899-Heart Failure, pubmed-meshheading:12374899-Heart Rate, pubmed-meshheading:12374899-Humans, pubmed-meshheading:12374899-Male, pubmed-meshheading:12374899-Middle Aged, pubmed-meshheading:12374899-Stroke Volume, pubmed-meshheading:12374899-Thiazoles, pubmed-meshheading:12374899-Thiazolidinediones, pubmed-meshheading:12374899-Time Factors, pubmed-meshheading:12374899-Vasodilator Agents, pubmed-meshheading:12374899-Ventricular Function, Left
pubmed:year
2002
pubmed:articleTitle
Troglitazone improves cardiac function in patients with congestive heart failure.
pubmed:affiliation
Division of Cardiology, Department of Medicine, Faculty of Medicine, Tottori University, 36-1 Nishimachi, Yonago 683-8504, Japan. k-ogino@umin.ac.jp
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial