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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2002-10-10
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pubmed:abstractText |
The selective estrogen receptor modulator arzoxifene and the rexinoid LG 100268 were active not only as single agents for prevention and treatment of breast cancer in the rat model that uses nitrosomethylurea as the carcinogen but also showed striking synergy, both preventively and therapeutically, in a series of six experiments with a total of 465 rats. Mechanistic studies in cell culture reported here suggest that enhancement of stromal-epithelial interactions may contribute to this synergy. The possible clinical use of the combination of arzoxifene and LG 100268 for prevention of breast cancer in women at high risk, for treatment of women in the adjuvant setting, or for treatment of end-stage disease should now be considered.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticarcinogenic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/LG 100268,
http://linkedlifedata.com/resource/pubmed/chemical/LY 353381,
http://linkedlifedata.com/resource/pubmed/chemical/Methylnitrosourea,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotinic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Selective Estrogen Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydronaphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Thiophenes,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3270-5
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:12374698-Animals,
pubmed-meshheading:12374698-Anticarcinogenic Agents,
pubmed-meshheading:12374698-Cells, Cultured,
pubmed-meshheading:12374698-Drug Synergism,
pubmed-meshheading:12374698-Drug Therapy, Combination,
pubmed-meshheading:12374698-Female,
pubmed-meshheading:12374698-Humans,
pubmed-meshheading:12374698-Mammary Neoplasms, Experimental,
pubmed-meshheading:12374698-Methylnitrosourea,
pubmed-meshheading:12374698-Neoplasm Invasiveness,
pubmed-meshheading:12374698-Nicotinic Acids,
pubmed-meshheading:12374698-Nitric Oxide Synthase,
pubmed-meshheading:12374698-Nitric Oxide Synthase Type II,
pubmed-meshheading:12374698-Piperidines,
pubmed-meshheading:12374698-Rats,
pubmed-meshheading:12374698-Selective Estrogen Receptor Modulators,
pubmed-meshheading:12374698-Stromal Cells,
pubmed-meshheading:12374698-Tetrahydronaphthalenes,
pubmed-meshheading:12374698-Thiophenes,
pubmed-meshheading:12374698-Transforming Growth Factor beta
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pubmed:year |
2002
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pubmed:articleTitle |
Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268.
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pubmed:affiliation |
Department of Pharmacology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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