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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2002-10-10
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pubmed:abstractText |
The product of the carcinoembryonic antigen (CEA) gene is an attractive candidate for T-cell-based immunotherapy because it is frequently expressed in epithelial solid carcinomas. Although many CEA peptide epitopes capable of stimulating CTLs have been identified, no MHC class II-restricted T helper epitope has yet been reported. Experimental Design: The amino acid sequence of CEA was examined for the presence of potential T helper epitopes, and candidate peptides were used to stimulate in vitro T-cell responses.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:Borras-CuestaFranciscoF,
pubmed-author:CelisEstebanE,
pubmed-author:HerraizMaiteM,
pubmed-author:HuarteEduardoE,
pubmed-author:KobayashiHiroyaH,
pubmed-author:LasarteJuan JoséJJ,
pubmed-author:OmiyaRyusukeR,
pubmed-author:PrietoJesúsJ,
pubmed-author:RuizMartaM,
pubmed-author:SangroBrunoB,
pubmed-author:SarobePabloP
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3219-25
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12374692-Algorithms,
pubmed-meshheading:12374692-Alleles,
pubmed-meshheading:12374692-Antigen Presentation,
pubmed-meshheading:12374692-Carcinoembryonic Antigen,
pubmed-meshheading:12374692-Colonic Neoplasms,
pubmed-meshheading:12374692-Cytotoxicity, Immunologic,
pubmed-meshheading:12374692-Epitope Mapping,
pubmed-meshheading:12374692-Epitopes, T-Lymphocyte,
pubmed-meshheading:12374692-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:12374692-HLA-DR Antigens,
pubmed-meshheading:12374692-HLA-DR Serological Subtypes,
pubmed-meshheading:12374692-HLA-DR4 Antigen,
pubmed-meshheading:12374692-HLA-DR7 Antigen,
pubmed-meshheading:12374692-Humans,
pubmed-meshheading:12374692-Lymphoma, T-Cell,
pubmed-meshheading:12374692-Peptide Fragments,
pubmed-meshheading:12374692-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:12374692-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:12374692-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Identification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigen.
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pubmed:affiliation |
Department of Pathology, Asahikawa Medical College, Asahikawa, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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