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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2002-10-9
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pubmed:abstractText |
BAG-1 is a multifunctional protein that interacts with a wide range of target molecules to regulate apoptosis, proliferation, transcription, metastasis and motility. Interaction with chaperone molecules may mediate many of the effects of BAG-1. The pathways regulated by BAG-1 play key roles in the development and progression of cancer and determining response to therapy, and there has been considerable interest in determining the clinical significance of BAG-1 expression in malignant cells. There is an emerging picture that BAG-1 expression is frequently altered in a range of human cancers relative to normal cells and a recent report suggests the exciting possibility that BAG-1 expression may have clinical utility as a prognostic marker in early breast cancer. However, other studies of BAG-1 expression in breast cancer and other cancer types have yielded differing results. It is important to view these findings in the context of current knowledge of BAG-1 expression and function. This review summarises recent progress in understanding the clinical significance of BAG-1 expression in cancer in light of our understanding of BAG-1 function.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-10477749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-10561207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-10576663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-10671488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-10964051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-11181661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-11222862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-11231577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-11248425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-11276257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-11494232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-11504752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-11600451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-11676916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-11738548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-11895913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-12081204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-12081206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-1517889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-9205104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-9396724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-9563821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-9565586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-9632144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-9679980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12373595-9747877
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 Cancer Research UK
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
834-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12373595-Apoptosis,
pubmed-meshheading:12373595-Carrier Proteins,
pubmed-meshheading:12373595-Cell Adhesion,
pubmed-meshheading:12373595-Cell Division,
pubmed-meshheading:12373595-Clinical Trials as Topic,
pubmed-meshheading:12373595-DNA-Binding Proteins,
pubmed-meshheading:12373595-Humans,
pubmed-meshheading:12373595-Neoplasm Metastasis,
pubmed-meshheading:12373595-Neoplasms,
pubmed-meshheading:12373595-Prognosis,
pubmed-meshheading:12373595-Transcription, Genetic,
pubmed-meshheading:12373595-Transcription Factors,
pubmed-meshheading:12373595-Tumor Markers, Biological
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pubmed:year |
2002
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pubmed:articleTitle |
BAG-1 expression and function in human cancer.
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pubmed:affiliation |
Cancer Research UK Oncology Unit, Cancer Sciences Division, Mail Point 824, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. R.Cutress@soton.ac.uk
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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