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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2002-10-9
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pubmed:abstractText |
Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the prolonged (but not acute) treatment with MPEP and with antidepressant drug-desipramine restored the learning deficit. The results indicate that the prolonged blockade of mGlu5 receptors exerts antidepressant-like effects in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0939-4451
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
213-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12373540-Animals,
pubmed-meshheading:12373540-Antidepressive Agents,
pubmed-meshheading:12373540-Antidepressive Agents, Tricyclic,
pubmed-meshheading:12373540-Desipramine,
pubmed-meshheading:12373540-Excitatory Amino Acid Antagonists,
pubmed-meshheading:12373540-Humans,
pubmed-meshheading:12373540-Learning,
pubmed-meshheading:12373540-Male,
pubmed-meshheading:12373540-Olfactory Bulb,
pubmed-meshheading:12373540-Pyridines,
pubmed-meshheading:12373540-Rats,
pubmed-meshheading:12373540-Rats, Wistar,
pubmed-meshheading:12373540-Receptors, Metabotropic Glutamate
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pubmed:year |
2002
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pubmed:articleTitle |
Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats.
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pubmed:affiliation |
Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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