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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-10-9
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pubmed:abstractText |
The discriminative effects of kappa-agonists may be mediated centrally, whereas their effects in a neuroendocrine biomarker assay (prolactin release) may be mediated by kappa-receptors in hypothalamic areas outside the blood-brain barrier. Prolactin may thus be a useful biomarker, due to its potential to provide quantitative pharmacodynamic data for kappa-opioid ligands in vivo. The potency of centrally penetrating kappa-agonists could be similar in these two assays, due to their ability to occupy kappa-receptor pools inside and outside the blood-brain barrier, following SC administration.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-20
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12373425-Animals,
pubmed-meshheading:12373425-Benzeneacetamides,
pubmed-meshheading:12373425-Discrimination (Psychology),
pubmed-meshheading:12373425-Dose-Response Relationship, Drug,
pubmed-meshheading:12373425-Female,
pubmed-meshheading:12373425-Macaca mulatta,
pubmed-meshheading:12373425-Neurosecretory Systems,
pubmed-meshheading:12373425-Prolactin,
pubmed-meshheading:12373425-Pyrrolidines,
pubmed-meshheading:12373425-Receptors, Opioid, kappa
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pubmed:year |
2002
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pubmed:articleTitle |
Comparison of the discriminative and neuroendocrine effects of centrally penetrating kappa-opioid agonists in rhesus monkeys.
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pubmed:affiliation |
The Rockefeller University (Box 171), 1230 York Avenue, New York, NY 10021, USA. butelme@mail.rockefeller.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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