Source:http://linkedlifedata.com/resource/pubmed/id/12373417
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2002-10-9
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pubmed:abstractText |
In studies assessing sustained attention in humans, performance is often characterised by a decline in function over time. This response pattern, termed the vigilance decrement, is sensitive to manipulations affecting task difficulty, and to reversal with psychostimulant drugs. A valid test of attention in non-human species requires both comparable characteristics of performance, and sensitivity to similar psychoactive drugs. The five-choice serial reaction time task (5-CSRTT) has been described as a test of sustained attention in the rat, however, studies describing vigilance decrements and performance effects of psychostimulants in this task are scarce.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0033-3158
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
164
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-41
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12373417-Aging,
pubmed-meshheading:12373417-Animals,
pubmed-meshheading:12373417-Arousal,
pubmed-meshheading:12373417-Attention,
pubmed-meshheading:12373417-Central Nervous System Stimulants,
pubmed-meshheading:12373417-Dose-Response Relationship, Drug,
pubmed-meshheading:12373417-Feeding Behavior,
pubmed-meshheading:12373417-Male,
pubmed-meshheading:12373417-Psychomotor Performance,
pubmed-meshheading:12373417-Rats,
pubmed-meshheading:12373417-Reaction Time
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pubmed:year |
2002
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pubmed:articleTitle |
Assessing a vigilance decrement in aged rats: effects of pre-feeding, task manipulation, and psychostimulants.
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pubmed:affiliation |
PRBN-B, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland. agrottick@arenapharm.com
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pubmed:publicationType |
Journal Article,
Comparative Study
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