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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2002-10-9
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pubmed:abstractText |
The aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2. The structures of 1 and 2 were established based on high-resolution NMR studies. Compounds 1 and 2 exhibited inhibitory activity (K(i)) of 30 and 5microM, respectively, in a chemokine receptor subtype 5 (CCR5) assay. Both compounds did not show any significant inhibition in a CXCR2 assay at 50microM, suggesting their selectivity for the CCR5 receptor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3203-5
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:12372534-Animals,
pubmed-meshheading:12372534-Glycosides,
pubmed-meshheading:12372534-Indicators and Reagents,
pubmed-meshheading:12372534-Magnetic Resonance Spectroscopy,
pubmed-meshheading:12372534-Molecular Conformation,
pubmed-meshheading:12372534-Receptors, CCR5,
pubmed-meshheading:12372534-Sea Cucumbers,
pubmed-meshheading:12372534-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:12372534-Tissue Extracts,
pubmed-meshheading:12372534-Triterpenes
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pubmed:year |
2002
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pubmed:articleTitle |
Two selective novel triterpene glycosides from sea cucumber, Telenata Ananas: inhibitors of chemokine receptor-5.
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pubmed:affiliation |
Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. vinod.hegde@spcorp.com
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pubmed:publicationType |
Journal Article
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