| pubmed-article:12372426 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12372426 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:12372426 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:12372426 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:12372426 | lifeskim:mentions | umls-concept:C0169101 | lld:lifeskim |
| pubmed-article:12372426 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:12372426 | lifeskim:mentions | umls-concept:C0162768 | lld:lifeskim |
| pubmed-article:12372426 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:12372426 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12372426 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12372426 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12372426 | pubmed:dateCreated | 2002-10-9 | lld:pubmed |
| pubmed-article:12372426 | pubmed:abstractText | TAK1 mitogen-activated protein kinase kinase kinase (MAP3K) is activated by its specific activator, TAK1-binding protein 1 (TAB1). A constitutively active TAK1 mutant has not yet been generated due to the indispensable requirement of TAB1 for TAK1 kinase activity. In this study, we generated a novel constitutively active TAK1 by fusing its kinase domain to the minimal TAK1-activation domain of TAB1. Co-immunoprecipitation assay demonstrated that these domains interacted intra-molecularly. The TAK1-TAB1 fusion protein showed a significant MAP3K activity in vitro and activated c-Jun N-terminal kinase/p38 MAPKs and IkappaB kinase in vivo, which was followed by increased production of interleukin-6. These results indicate that the fusion protein is useful for characterizing the physiological roles of the TAK1-TAB1 complex. | lld:pubmed |
| pubmed-article:12372426 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12372426 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12372426 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12372426 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12372426 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:12372426 | pubmed:author | pubmed-author:SakuraiHiroak... | lld:pubmed |
| pubmed-article:12372426 | pubmed:author | pubmed-author:MizukamiJunko... | lld:pubmed |
| pubmed-article:12372426 | pubmed:author | pubmed-author:SatoNaoyaN | lld:pubmed |
| pubmed-article:12372426 | pubmed:author | pubmed-author:NishiAkitoA | lld:pubmed |
| pubmed-article:12372426 | pubmed:author | pubmed-author:MiyoshiHideta... | lld:pubmed |
| pubmed-article:12372426 | pubmed:author | pubmed-author:SugitaTakahis... | lld:pubmed |
| pubmed-article:12372426 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12372426 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:12372426 | pubmed:volume | 297 | lld:pubmed |
| pubmed-article:12372426 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12372426 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12372426 | pubmed:pagination | 1277-81 | lld:pubmed |
| pubmed-article:12372426 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:12372426 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12372426 | pubmed:articleTitle | TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways. | lld:pubmed |
| pubmed-article:12372426 | pubmed:affiliation | Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., 16-89 Kashima 3-chome, Yodogawa-ku, 532-8505, Osaka, Japan. | lld:pubmed |
| pubmed-article:12372426 | pubmed:publicationType | Journal Article | lld:pubmed |
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