Linked Life Data

12372239

Source:http://linkedlifedata.com/resource/pubmed/id/12372239

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2002-10-9
pubmed:abstractText
Both microbiological and epidemiological reading of the antibiogram can be performed without additional pharmacokinetic or pharmacodynamic concepts. However, when the aim is a clinical reading of the antibiogram, knowledge of the pharmacokinetics of antimicrobial agents and of all phenomena occurring between antimicrobial agents and microorganisms is imperative. Pharmacokinetics includes the study of absorption, distribution, metabolism and elimination of drugs. These data provide information on the active concentrations of antimicrobial agents in blood and other fluids as well as in the tissues where infection may develop. Knowledge of metabolism and of elimination pathways complete the main pharmacokinetic parameters of antimicrobial agents. The bactericidal effect of antimicrobial agents can be either concentration- or time-dependent. In the former, high concentrations of antimicrobial agents, much higher than their corresponding MICs, are needed, while in the latter, maintaining the concentration of antimicrobial agents at levels slightly higher than their MICs over time is more important. With these concepts, a microbiological-pharmacological reading of the antibiogram, taking into account dosage, administration pathway and location of the infectious process among other factors, can be achieved. Most working groups, either national or from abroad, have considered both pharmacokinetics and pharmacodynamics in interpretative reading of the antibiogram. In all cases, breakpoints for susceptibility and resistance should be corrected on the basis of data from well designed and performed clinical trials. Clinically oriented breakpoints do not necessarily have to be the same as those based on microbiological or epidemiological concepts, but clinical microbiologists should be able to give an appropriate response to the question and to the application based on that response.
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0213-005X
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
407-11; quiz 412
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
[Pharmacokinetic and pharmacodynamic concepts for an interpretative reading of the antibiogram].
pubmed:affiliation
Departamento de Microbiología Médica. Fundación Jiménez Díaz. Madrid. España. fsoriano@microb.net
pubmed:publicationType
Journal Article, English Abstract, Review