Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2002-10-9
pubmed:abstractText
This study demonstrates that pharmacological manipulation of the dopamine (DA) receptors can modulate the size of the axonal tree of substantia nigra pars compacta (SNpc) neurons in mice. Pharmacological blockade or genetic ablation of the D2 receptor (D2R) resulted in sprouting of DA SNpc neurons whereas treatment with a D2 agonist resulted in pruning of the terminal arbor of these neurons. Agents such as cocaine, that indirectly stimulate D2R, also resulted in reduced terminal arbor. Specific D1 agonists or antagonists had no effect on the density of DA terminals in the striatum. We conclude that the D2 receptor has a central role in regulating the size of the terminal arbor of nigrostriatal neurons. These findings have implications relating to the use of dopaminergic agonists in the management of Parkinson's disease and in controlling plasticity following injury, loss or transplantation of DA neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0953-816X
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
787-94
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12372014-Animals, pubmed-meshheading:12372014-Axons, pubmed-meshheading:12372014-Cocaine, pubmed-meshheading:12372014-Dopamine, pubmed-meshheading:12372014-Dopamine Agonists, pubmed-meshheading:12372014-Dopamine Antagonists, pubmed-meshheading:12372014-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:12372014-Immunohistochemistry, pubmed-meshheading:12372014-Male, pubmed-meshheading:12372014-Membrane Glycoproteins, pubmed-meshheading:12372014-Membrane Transport Proteins, pubmed-meshheading:12372014-Mice, pubmed-meshheading:12372014-Mice, Knockout, pubmed-meshheading:12372014-Nerve Tissue Proteins, pubmed-meshheading:12372014-Rats, pubmed-meshheading:12372014-Rats, Wistar, pubmed-meshheading:12372014-Receptors, Dopamine D1, pubmed-meshheading:12372014-Receptors, Dopamine D2, pubmed-meshheading:12372014-Substantia Nigra
pubmed:year
2002
pubmed:articleTitle
Effects of long-term treatment with dopamine receptor agonists and antagonists on terminal arbor size.
pubmed:affiliation
Neurosciences Group, Department of Medicine, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton 3168, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't