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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-10-9
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pubmed:abstractText |
Evidence indicates that urinary protein is associated with tubulointerstitial damage and thus it is an aggravating factor for chronic renal disease. As free fatty acids (FFAs) are bound to serum albumin, we hypothesized that FFAs were overloaded to the proximal tubule in massive proteinuria and thus caused tubulointerstitial damage. To test this hypothesis, massive proteinuria was provoked in mice and the renal damage examined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1628-37
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12371963-Albuminuria,
pubmed-meshheading:12371963-Animals,
pubmed-meshheading:12371963-Antibodies,
pubmed-meshheading:12371963-Blood Pressure,
pubmed-meshheading:12371963-Body Weight,
pubmed-meshheading:12371963-Cells, Cultured,
pubmed-meshheading:12371963-Endotoxins,
pubmed-meshheading:12371963-Fatty Acids, Nonesterified,
pubmed-meshheading:12371963-Female,
pubmed-meshheading:12371963-Kidney Failure, Chronic,
pubmed-meshheading:12371963-Kidney Tubules, Proximal,
pubmed-meshheading:12371963-Macrophages,
pubmed-meshheading:12371963-Mice,
pubmed-meshheading:12371963-Mice, Inbred BALB C,
pubmed-meshheading:12371963-Serum Albumin,
pubmed-meshheading:12371963-Serum Albumin, Bovine
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pubmed:year |
2002
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pubmed:articleTitle |
Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage.
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pubmed:affiliation |
Internal Medicine, the University of Tokyo, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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