Source:http://linkedlifedata.com/resource/pubmed/id/12369080
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
20
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pubmed:dateCreated |
2002-10-7
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pubmed:abstractText |
The generalized estimating equations (GEE) approach is commonly used to model incomplete longitudinal binary data. When drop-outs are missing at random through dependence on observed responses (MAR), GEE may give biased parameter estimates in the model for the marginal means. A weighted estimating equations approach gives consistent estimation under MAR when the drop-out mechanism is correctly specified. In this approach, observations or person-visits are weighted inversely proportional to their probability of being observed. Using a simulation study, we compare the performance of unweighted and weighted GEE in models for time-specific means of a repeated binary response with MAR drop-outs. Weighted GEE resulted in smaller finite sample bias than GEE. However, when the drop-out model was misspecified, weighted GEE sometimes performed worse than GEE. Weighted GEE with observation-level weights gave more efficient estimates than a weighted GEE procedure with cluster-level weights.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0277-6715
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2002 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3035-54
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading | |
pubmed:year |
2002
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pubmed:articleTitle |
Performance of weighted estimating equations for longitudinal binary data with drop-outs missing at random.
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pubmed:affiliation |
Department of Biostatistics, CB #7420, School of Public Health, University of North Carolina, Chapel Hill 27599, USA. jpreisse@bios.unc.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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