Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2002-10-7
pubmed:abstractText
The generalized estimating equations (GEE) approach is commonly used to model incomplete longitudinal binary data. When drop-outs are missing at random through dependence on observed responses (MAR), GEE may give biased parameter estimates in the model for the marginal means. A weighted estimating equations approach gives consistent estimation under MAR when the drop-out mechanism is correctly specified. In this approach, observations or person-visits are weighted inversely proportional to their probability of being observed. Using a simulation study, we compare the performance of unweighted and weighted GEE in models for time-specific means of a repeated binary response with MAR drop-outs. Weighted GEE resulted in smaller finite sample bias than GEE. However, when the drop-out model was misspecified, weighted GEE sometimes performed worse than GEE. Weighted GEE with observation-level weights gave more efficient estimates than a weighted GEE procedure with cluster-level weights.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0277-6715
pubmed:author
pubmed:copyrightInfo
Copyright 2002 John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3035-54
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Performance of weighted estimating equations for longitudinal binary data with drop-outs missing at random.
pubmed:affiliation
Department of Biostatistics, CB #7420, School of Public Health, University of North Carolina, Chapel Hill 27599, USA. jpreisse@bios.unc.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't