Linked Life Data

12368408

Source:http://linkedlifedata.com/resource/pubmed/id/12368408

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2002-10-7
pubmed:abstractText
Copper is an essential metal during development. Female Swiss Webster mice were fed a modified AIN-76A diet low in copper (0.3 mg Cu/kg and 43 mg Fe/kg; -Cu). One-half the mice received copper in their drinking water (20 mg Cu/L; +Cu). Female mice were mated to normal males and offered the -Cu or +Cu treatments starting at gestational d 13. Treatments did not affect litter size or pregnancy outcome. For three litters of +Cu mice, 26/26 offspring born were weaned on postnatal d 21 (P21). For three litters of -Cu dams, 0/26 pups survived beyond P13. The -Cu dams kept on treatment for this 3-wk period were killed and compared biochemically with +Cu dams and to nonpregnant females that were kept on the +Cu or -Cu treatment and fed the same diet for 3 wk. Compared with +Cu dams, -Cu dams had 48% lower hematocrits, 89% lower plasma ceruloplasmin activities, 45% lower liver copper level, and > 2-fold higher liver iron concentration. The -Cu, nonpregnant female mice did not differ in any of these copper status indicators from the +Cu dams or nonpregnant, +Cu females. When -Cu treatment was delayed until embryonic d 19, all -Cu pups survived weaning. Additional studies should be conducted to establish the human copper requirement for perinatal development and determine whether the 11 and 44% extra copper intakes recommended for pregnancy and lactation in the new United States recommended dietary allowance are sufficient.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3142-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
The timing of perinatal copper deficiency in mice influences offspring survival.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, University of Minnesota, Duluth 55812, USA. jprohask@d.umn.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.