|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0003280,
umls-concept:C0005789,
umls-concept:C0033706,
umls-concept:C0042295,
umls-concept:C0042890,
umls-concept:C0087111,
umls-concept:C0439849,
umls-concept:C0441889,
umls-concept:C0442027,
umls-concept:C0525032,
umls-concept:C0585064,
umls-concept:C1515655,
umls-concept:C1879547
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|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2002-10-7
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|
pubmed:abstractText |
In vitro studies have shown that the rate of prothrombin activation is linearly related to the concentration of factor II (FII) in the assay system, suggesting a key role of prothrombin levels in the expression of the antithrombotic activity of oral anticoagulant treatment (OAT). We investigated the in vivo relationship between prothrombin activation and vitamin K-dependent clotting factor levels during the early and steady phases of OAT in patients and in healthy volunteers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0390-6078
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1074-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12368163-Acenocoumarol,
pubmed-meshheading:12368163-Administration, Oral,
pubmed-meshheading:12368163-Adult,
pubmed-meshheading:12368163-Aged,
pubmed-meshheading:12368163-Anticoagulants,
pubmed-meshheading:12368163-Factor VII,
pubmed-meshheading:12368163-Factor X,
pubmed-meshheading:12368163-Female,
pubmed-meshheading:12368163-Humans,
pubmed-meshheading:12368163-Kinetics,
pubmed-meshheading:12368163-Male,
pubmed-meshheading:12368163-Middle Aged,
pubmed-meshheading:12368163-Peptide Fragments,
pubmed-meshheading:12368163-Protein C,
pubmed-meshheading:12368163-Prothrombin,
pubmed-meshheading:12368163-Time Factors,
pubmed-meshheading:12368163-Vitamin K,
pubmed-meshheading:12368163-Warfarin
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pubmed:year |
2002
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pubmed:articleTitle |
Relationship between international normalized ratio values, vitamin K-dependent clotting factor levels and in vivo prothrombin activation during the early and steady phases of oral anticoagulant treatment.
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pubmed:affiliation |
Coagulation Service and Thrombosis Research Unit, IRCCS H S.Raffaele, Milan, Italy. armando.dangelo@hsr.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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