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rdf:type |
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lifeskim:mentions |
umls-concept:C0018837,
umls-concept:C0020429,
umls-concept:C0021368,
umls-concept:C0024501,
umls-concept:C0027752,
umls-concept:C0441889,
umls-concept:C0442805,
umls-concept:C0682690,
umls-concept:C0721534,
umls-concept:C1120843,
umls-concept:C1155551,
umls-concept:C1421467
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pubmed:issue |
1
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pubmed:dateCreated |
2002-10-7
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pubmed:abstractText |
Peripheral inflammation induces p38 MAPK activation in the soma of C fiber nociceptors in the dorsal root ganglion (DRG) after 24 hr. Inflammation also increases protein, but not mRNA levels, of the heat-gated ion channel TRPV1 (VR1) in these cells, which is then transported to peripheral but not central C fiber terminals. Inhibiting p38 activation in the DRG reduces the increase in TRPV1 in the DRG and inflamed skin and diminishes inflammation-induced heat hypersensitivity without affecting inflammatory swelling or basal pain sensitivity. p38 activation in the DRG is secondary to peripheral production of NGF during inflammation and is required for NGF-induced increases in TRPV1. The activation of p38 in the DRG following retrograde NGF transport, by increasing TRPV1 levels in nociceptor peripheral terminals in a transcription-independent fashion, contributes to the maintenance of inflammatory heat hypersensitivity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-68
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12367506-Animals,
pubmed-meshheading:12367506-Cells, Cultured,
pubmed-meshheading:12367506-Dose-Response Relationship, Drug,
pubmed-meshheading:12367506-Ganglia, Spinal,
pubmed-meshheading:12367506-Hyperalgesia,
pubmed-meshheading:12367506-Immunohistochemistry,
pubmed-meshheading:12367506-Inflammation,
pubmed-meshheading:12367506-Male,
pubmed-meshheading:12367506-Mice,
pubmed-meshheading:12367506-Mice, Knockout,
pubmed-meshheading:12367506-Mitogen-Activated Protein Kinases,
pubmed-meshheading:12367506-Nerve Fibers, Unmyelinated,
pubmed-meshheading:12367506-Nerve Growth Factor,
pubmed-meshheading:12367506-Neuralgia,
pubmed-meshheading:12367506-Neurons, Afferent,
pubmed-meshheading:12367506-Nociceptors,
pubmed-meshheading:12367506-Posterior Horn Cells,
pubmed-meshheading:12367506-Rats,
pubmed-meshheading:12367506-Rats, Sprague-Dawley,
pubmed-meshheading:12367506-Receptors, Drug,
pubmed-meshheading:12367506-Up-Regulation,
pubmed-meshheading:12367506-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2002
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pubmed:articleTitle |
p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia.
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pubmed:affiliation |
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. ji@helix.mgh.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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