Structural and metabolic abnormalities in the hippocampal region in medial temporal lobe epilepsy (mTLE) are well described; less is known about extrahippocampal changes. This study was designed to characterize extrahippocampal metabolic abnormalities in mTLE with magnetic resonance spectroscopy in combination with tissue segmentation and volumetry of gray and white matter.
Department of Veterans Affairs (DVA) Medical Center, Magnetic Resonance Spectroscopy Unit, University of California San Francisco, California 94143-0138, USA.