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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2002-10-4
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pubmed:abstractText |
Cells lacking the ATM (ataxia telangectasia mutated) gene are hypersensitive to DNA damage caused by a variety of insults. ATM may regulate oxidative stress-induced signaling cascades involving nuclear factor-kappaB (NF-kappaB), a transcription factor that is upstream of a wide variety of stress-responsive genes. We investigated the potential interaction of ATM and NF-kappaB after oxygen-glucose deprivation (OGD) in cerebral endothelial cells (CECs).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Mitochondrial,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/SN50 peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ataxia telangiectasia mutated...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2471-7
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:12364740-Animals,
pubmed-meshheading:12364740-Apoptosis,
pubmed-meshheading:12364740-Brain,
pubmed-meshheading:12364740-Caspases,
pubmed-meshheading:12364740-Cell Cycle Proteins,
pubmed-meshheading:12364740-Cell Hypoxia,
pubmed-meshheading:12364740-Cells, Cultured,
pubmed-meshheading:12364740-Cytoprotection,
pubmed-meshheading:12364740-DNA,
pubmed-meshheading:12364740-DNA, Mitochondrial,
pubmed-meshheading:12364740-DNA Damage,
pubmed-meshheading:12364740-DNA-Binding Proteins,
pubmed-meshheading:12364740-Endothelium, Vascular,
pubmed-meshheading:12364740-Enzyme Activation,
pubmed-meshheading:12364740-Glucose,
pubmed-meshheading:12364740-Hypoxia, Brain,
pubmed-meshheading:12364740-Mice,
pubmed-meshheading:12364740-NF-kappa B,
pubmed-meshheading:12364740-Oligonucleotides, Antisense,
pubmed-meshheading:12364740-Peptides,
pubmed-meshheading:12364740-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12364740-Proteins,
pubmed-meshheading:12364740-RNA, Messenger,
pubmed-meshheading:12364740-Signal Transduction,
pubmed-meshheading:12364740-Tumor Suppressor Proteins,
pubmed-meshheading:12364740-Up-Regulation
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pubmed:year |
2002
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pubmed:articleTitle |
ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity and downstream apoptotic cascade in mouse cerebrovascular endothelial cells.
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pubmed:affiliation |
Department of Neurology and Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Mo 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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