Source:http://linkedlifedata.com/resource/pubmed/id/12364554
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2002-10-4
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pubmed:abstractText |
We investigated the effects of atorvastatin on the lipid and the apoA-I-containing HDL subpopulation profiles in 86 patients with established coronary heart disease (CHD). The entire drug treatment period lasted 12 weeks (4-week periods of 20 then 40, then 80 mg/day). Each dose of atorvastatin treatment resulted in significant reductions in plasma total-C, LDL-C, and triglyceride (TG), and non-significant increases in HDL-C levels compared with placebo treatment. ApoA-I levels did not change significantly during any of the treatment periods. Despite the modest increase of HDL-C (6%, 7%, 5%) and no change in apoA-I levels, the distribution of the apoA-I-containing HDL subpopulations changed significantly during each treatment period. There were significant increases in the concentrations of the large LpA-I alpha-1 (24%, 39%, 26%) and pre alpha-1 (51%, 61%, 63%) subpopulations at the expense of the small lipoprotein LpA-I:A-II alpha-3 subpopulations which decreased on all doses, and the decreases were significant on the 40 and 80 mg/day doses (6%, 5%). Atorvastatin influences the lipid-related risk for CHD in two ways: first, it significantly decreases LDL-C and TG levels while increasing HDL-C, and second, it significantly shifts the HDL subpopulation profile of CHD patients toward that observed in subjects without CHD.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticholesteremic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Heptanoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/atorvastatin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-2275
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1701-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12364554-Adult,
pubmed-meshheading:12364554-Aged,
pubmed-meshheading:12364554-Anticholesteremic Agents,
pubmed-meshheading:12364554-Apolipoprotein A-I,
pubmed-meshheading:12364554-Coronary Disease,
pubmed-meshheading:12364554-Cross-Over Studies,
pubmed-meshheading:12364554-Dose-Response Relationship, Drug,
pubmed-meshheading:12364554-Drug Administration Schedule,
pubmed-meshheading:12364554-Female,
pubmed-meshheading:12364554-Heptanoic Acids,
pubmed-meshheading:12364554-Humans,
pubmed-meshheading:12364554-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:12364554-Lipids,
pubmed-meshheading:12364554-Lipoproteins, HDL,
pubmed-meshheading:12364554-Male,
pubmed-meshheading:12364554-Middle Aged,
pubmed-meshheading:12364554-Pyrroles
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pubmed:year |
2002
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pubmed:articleTitle |
Effects of atorvastatin on the HDL subpopulation profile of coronary heart disease patients.
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pubmed:affiliation |
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, MA, USA. basztslos@hnrc.tufts.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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