Source:http://linkedlifedata.com/resource/pubmed/id/12364492
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2002-10-4
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| pubmed:abstractText |
This study investigated the role of trigeminal subnucleus caudalis (Vc) P2X receptors in the mediation of central sensitization induced in nociceptive neurons in subnucleus oralis (Vo) by mustard oil (MO) application to the tooth pulp in anesthetized rats. MO application produced a long-lasting central sensitization reflected in neuroplastic changes (i.e., increases in neuronal mechanoreceptive field size and responses to innocuous and noxious mechanical stimuli) in Vo nociceptive neurons. Twenty minutes after MO application, the intrathecal (i.t.) administration to the rostral Vc of the selective P2X(1), P2X(3), and P2X(2/3) receptor antagonist, 2'-(or 3'-)O-trinitrophenyl-ATP (TNP-ATP), significantly and reversibly attenuated the MO-induced central sensitization for more than 15 min; saline administration had no effect. Administration to the rostral Vc of the selective P2X(1), P2X(3), and P2X(2/3) receptor agonist, alpha,beta-methylene ATP (alpha,beta-meATP, i.t.) produced abrupt and significant neuroplastic changes in Vo nociceptive neurons, followed by neuronal desensitization as evidenced by the ineffectiveness of a second i.t. application of alpha,beta-meATP and subsequent MO application to the pulp. Administration to the rostral Vc of the selective P2X(1) receptor agonist beta,gamma-methylene ATP (beta,gamma-meATP, i.t.) produced no significant neuroplastic changes per se and did not affect the subsequent MO-induced neuroplastic changes in Vo nociceptive neurons. These results suggest that P2X(3) and possibly also the P2X(2/3) receptor subtypes in Vc may play a role in the initiation and maintenance of central sensitization in Vo nociceptive neurons induced by MO application to the pulp.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2',3'-O-(2,4,6-trinitro-cyclohexadie...,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Oils,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2X,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/alpha,beta-methyleneadenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/mustard oil
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0022-3077
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
88
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1614-24
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:12364492-Adenosine Triphosphate,
pubmed-meshheading:12364492-Animals,
pubmed-meshheading:12364492-Antineoplastic Agents,
pubmed-meshheading:12364492-Dental Pulp,
pubmed-meshheading:12364492-Facial Pain,
pubmed-meshheading:12364492-Fluorescent Dyes,
pubmed-meshheading:12364492-Male,
pubmed-meshheading:12364492-Mustard Plant,
pubmed-meshheading:12364492-Neurons, Afferent,
pubmed-meshheading:12364492-Nociceptors,
pubmed-meshheading:12364492-Physical Stimulation,
pubmed-meshheading:12364492-Plant Extracts,
pubmed-meshheading:12364492-Plant Oils,
pubmed-meshheading:12364492-Pressure,
pubmed-meshheading:12364492-Rats,
pubmed-meshheading:12364492-Rats, Sprague-Dawley,
pubmed-meshheading:12364492-Receptors, Purinergic P2,
pubmed-meshheading:12364492-Receptors, Purinergic P2X,
pubmed-meshheading:12364492-Sodium Chloride,
pubmed-meshheading:12364492-Stimulation, Chemical,
pubmed-meshheading:12364492-Touch,
pubmed-meshheading:12364492-Trigeminal Caudal Nucleus
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| pubmed:year |
2002
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| pubmed:articleTitle |
P2X receptors in trigeminal subnucleus caudalis modulate central sensitization in trigeminal subnucleus oralis.
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| pubmed:affiliation |
Faculty of Dentistry, University of Toronto, Ontario M5G 1G6, Canada.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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